Evidence map›Paper›PMID 36552990›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Eplet-Predicted Antigens: An Attempt to Introduce Eplets into Unacceptable Antigen Determination and Calculated Panel-Reactive Antibody Calculation Facilitating Kidney Allocation.

Wenrui Wu, Huanxi Zhang, Jinghong Tan, Qian Fu, Jun Li, Chenglin Wu, Huiting Huang, Bowen Xu, Liuting Ling, Longshan Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Wenrui WuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0001-7245-4659
Huanxi ZhangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Jinghong TanOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Qian FuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Jun LiOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Chenglin WuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Huiting HuangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Bowen XuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liuting LingOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Longshan LiuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0001-5199-076X
Xiaojun SuOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Changxi WangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Sun Yat-sen University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2020A1515010884Guangdong Provincial International Cooperation Base of Science and Technology 2020A0505020003Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology 2017B030314018Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology 2020B1212060026National Natural Science Foundation of China 81870511National Natural Science Foundation of China 82170770Science and Technology Planning Project of Guangzhou City 201903010058Science and Technology Planning Project of Guangzhou City 202201011318
6 · The paper itself

Abstract

(1) Calculated panel-reactive antibody (CPRA) is a measure of sensitization based on unacceptable antigens (UAs). Determination of UAs based on single-antigen bead assays at allele or antigen levels may be inappropriate. We aimed to introduce eplets for better assessment of sensitization; (2) 900 recipients and 1427 donors were enrolled for candidate or donor pools, respectively. Eplets were from the HLA Epitope Registry. UAs were determined by anti-HLA antibodies identified using LIFECODES Single Antigen (LSA) kits. CPRA values were calculated using a simplified method of donor filtering; (3) HLA antigens containing all eplets of an HLA antigen in LSA kits (LSA antigen) were defined as eplet-predicted (EP) antigens, the reactivity of which could be predicted by that LSA antigen. High reactivity concordance was found between LSA and EP antigens. More HLA antigens were covered by EP antigens in the population than LSA antigens. CPRA values at the EP level were higher than at the allele level and lower than at the antigen level. The EP antigens facilitated UA determination for non-LSA antigens and avoided acute rejection; (4) UA determination using EP antigens can lead to more accurate assessment of sensitization, enabling a high probability of compatible organs and a low risk of adverse outcomes.

Indexed as

calculated panel-reactive antibodyHLA epletorgan allocationsingle-antigen beadunacceptable antigen

Identifiers

PMID36552990
PMCPMC9776513
OpenAlexW4310191648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.