ArticleDiagnostics (Basel, Switzerland)2022
Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association between immune-inflammatory index and osteoporosis: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Associations of novel complete blood count-derived inflammatory markers with psoriasis: a systematic review and meta-analysis.Archives of dermatological research · 2024Pooled it
- Article
- Immune-metabolic convergence in skeletal remodeling disorders: shared osteoimmune, senescent and lipid mechanisms across aging-related and immune-mediated bone disease.Frontiers in immunology · 2026Review
- Article
- Inflammatory indices and bone density in osteoporosis: A cross-sectional study.Journal of education and health promotion · 2026Article
- Article
- Prognostic value of three inflammatory markers for mortality after hip fracture in the geriatric population.Scientific reports · 2025Article
- Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis.International journal of molecular sciences · 2025Article
- Relationship between serum ApoB-100 and lumbar bone mineral density in postmenopausal women: a retrospective analysis of a health screening population.Frontiers in endocrinology · 2025Article
- Machine Learning-Based Interpretable Screening for Osteoporosis in Tuberculosis Spondylitis Patients Using Blood Test Data: Development and External Validation of a Novel Web-Based Risk Calculator with Explainable Artificial Intelligence (XAI).Infection and drug resistance · 2025Article
- Article
- Re-evaluating basophil count as a hematological indicator for bone density: a subgroup analysis from an East Asian population.Frontiers in endocrinology · 2025Article
- From Inflammation to Bone Loss: The Multifaceted Role of Neutrophils in Osteoporosis.International journal of inflammation · 2025Review
- Advanced lung cancer inflammation index as a diagnostic indicator of bone turnover in osteoporotic fracture patients: a non-linear analysis.Frontiers in endocrinology · 2025Article
- NLR and PLR as Adjunctive Markers of MRI-Derived Vertebral Bone Quality in a Preoperative Lumbar Cohort.Therapeutics and clinical risk management · 2025Article
- Correlation study of multiple inflammatory indices and vertebral compression fracture: A cross-sectional study.Journal of clinical & translational endocrinology · 2024Article
- Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune-Inflammatory-Metabolic Markers and Related Conceptual Issues.Journal of clinical medicine · 2024Article
- Association between diabetes mellitus and trochanteric bone mineral density in individuals with osteoporotic fractures: a retrospective study.Frontiers in medicine · 2024Article
- Association between advanced lung cancer inflammation index and osteoporosis in patients with type 2 diabetes mellitus: evidence from NHANES.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is characterized by low bone mass and increased bone fragility. Numerous studies have suggested that inflammation contributes to its pathogenesis. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, noninvasive biomarkers that can reflect the inflammation status on human body. However, evidence on their associations with osteoporosis remains scant. The PubMed, Embase, and Cochrane Library databases were searched for relevant studies from their inception to April 2022. Observational studies providing complete NLR or PLR data in both the osteoporosis and normal bone mineral density (BMD) groups were included. Studies involving individuals at risk of secondary osteoporosis or restricted to a certain disease population were excluded. The main outcome was the associations of NLR and PLR with osteoporosis. Between-group differences were measured using mean differences (MDs) and 95% confidence intervals (CIs). In our analysis, both NLR and PLR were significantly higher in the osteoporosis group (MD = 0.494, 95% CI: 0.339−0.649, p < 0.0001; MD = 23.33, 95% CI: 4.809−41.850, p = 0.014, respectively) than in the normal BMD group. NLR was significantly higher in postmenopausal women with osteoporosis (MD = 0.432, 95% CI: 0.309−0.544, p < 0.0001). Our findings suggest the associations of NLR and PLR with osteoporosis. NLR and PLR constitute potential targets in osteoporosis screening.
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