Evidence map›Paper›PMID 36552912›Full record

ReviewDiagnostics (Basel, Switzerland)2022

New Insights in Pleural Mesothelioma Classification Update: Diagnostic Traps and Prognostic Implications.

Maria Giovanna Mastromarino, Alessandra Lenzini, Vittorio Aprile, Greta Alì, Diana Bacchin, Stylianos Korasidis, Marcello Carlo Ambrogi, Marco Lucchi

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria Giovanna MastromarinoDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0001-9291-5619
Alessandra LenziniDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.
Vittorio AprileDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.
Greta AlìAnatomic Pathology Section, Department of Surgical, Medical, Molecular Pathology and Critical Area, University di Pisa, 56124 Pisa, Italy.
Diana BacchinDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0002-5706-0974
Stylianos KorasidisDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0002-8818-6553
Marcello Carlo AmbrogiDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.
Marco LucchiDepartment of Cardiology, Thoracic and Vascular Medicine, Division of Thoracic Surgery, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0001-9909-6820
Azienda Ospedaliera Universitaria Pisana · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2021 WHO Classification of Tumors of the Pleura has introduced significant changes in mesothelioma codification beyond the three current histological subtypes-epithelioid, sarcomatoid and biphasic. Major advances since the 2015 WHO classification include nuclear grading and the introduction of architectural patterns, cytological and stromal features for epithelioid diffuse mesothelioma. Mesothelioma in situ has been recognized as a diagnostic category. Demonstration of loss of BAP1 or MTAP by immunohistochemistry, or CDKN2A homozygous deletion by FISH, is valuable in establishing the diagnosis of epithelioid mesothelioma. Recent emerging data proved that grading and histological subtypes have prognostic implications and may be helpful to patient risk stratification and clinical management. Nevertheless, the latest mesothelioma classification increases the already non-negligible diagnostic pitfalls, especially concerning differential diagnosis of pre-invasive tumors. In this review, recent changes in histologic classification of mesothelioma and advances in molecular markers are presented and their relation to diagnostic challenges and prognostic implications is discussed.

Indexed as

epithelioid mesotheliomahistological subtypeshistologymalignant pleural mesotheliomamesothelioma classificationmesothelioma diagnosistumor grade

Identifiers

PMID36552912
PMCPMC9776784
OpenAlexW4309721815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.