Evidence map›Paper›PMID 36552580›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema.

John M Pezzuto, Asim Dave, Eun-Jung Park, Diren Beyoğlu, Jeffrey R Idle

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

John M PezzutoCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
Asim DaveImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Eun-Jung ParkDivision of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.
Diren BeyoğluCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
Jeffrey R IdleCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.ORCID 0000-0002-6143-1520
Western New England University · USLong Island University · USMemorial Sloan Kettering Cancer Center · USUniversity of Massachusetts Chan Medical School · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
California Table Grape Commission n/aNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Over three million Americans are affected by skin cancer each year, largely as a result of exposure to sunlight. The purpose of this study was to determine the potential of grape consumption to modulate UV-induced skin erythema. With 29 human volunteers, we report that nine demonstrated greater resistance to UV irradiation of the skin after consuming the equivalent of three servings of grapes per day for two weeks. We further explored any potential relationship to the gut-skin axis. Alpha- and beta-diversity of the gut microbiome were not altered, but grape consumption modulated microbiota abundance, enzyme levels, and KEGG pathways. Striking differences in the microbiome and metabolome were discerned when comparing the nine individuals showing greater UV resistance with the 20 non-responders. Notably, three urinary metabolites, 2'-deoxyribonic acid, 3-hydroxyphenyl acetic and

Indexed as

bacterial metabolismDNA damage responseenzyme turnovermetabolomicsmicrobiomeradiation biologyskin

Identifiers

PMID36552580
PMCPMC9774720
OpenAlexW4310388793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.