Evidence map›Paper›PMID 36552568›Full record

ArticleAntioxidants (Basel, Switzerland)2022

The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of

Rajalakshmi Balasubramanian, Koichi Hori, Takayuki Shimizu, Shingo Kasamatsu, Kae Okamura, Kan Tanaka, Hideshi Ihara, Shinji Masuda

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  8. In the AlphaproteobacteriumAntioxidants (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rajalakshmi BalasubramanianDepartment of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Koichi HoriDepartment of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Takayuki ShimizuGraduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan.ORCID 0000-0002-2956-9386
Shingo KasamatsuDepartment of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 599-8531, Japan.ORCID 0000-0002-3094-8543
Kae OkamuraDepartment of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 599-8531, Japan.
Kan TanakaLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8501, Japan.ORCID 0000-0001-7560-7884
Hideshi IharaDepartment of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 599-8531, Japan.
Shinji MasudaDepartment of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Tokyo Institute of Technology · JPOsaka Metropolitan University · JPTokyo University of the Arts · JP

Funding

Grant-in-Aid for Scientific Research, KAKENHI 21H05271Ohsumi Frontier Science Foundation N03_Masuda
6 · The paper itself

Abstract

Compositions and activities of bacterial flora in the gastrointestinal tract significantly influence the metabolism, health, and disease of host humans and animals. These enteric bacteria can switch between aerobic and anaerobic growth if oxygen tension becomes limited. Interestingly, the switching mechanism is important for preventing reactive oxygen species (ROS) production and antibiotic tolerance. Studies have also shown that intracellular and extracellular sulfide molecules are involved in this switching control, although the mechanism is not fully clarified. Here, we found that YgaV, a sulfide-responsive transcription factor SqrR/BigR homolog, responded to sulfide compounds in vivo and in vitro to control anaerobic respiratory gene expression. YgaV also responded to H

Indexed as

antibioticsEscherichia colihydrogen sulfidereactive sulfur speciesSqrRYgaV

Identifiers

PMID36552568
PMCPMC9774250
OpenAlexW4310191144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.