Evidence map›Paper›PMID 36552561›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS.

Cheol Park, Hee-Jae Cha, Min Yeong Kim, EunJin Bang, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jeong Sook Noh, Gi-Young Kim, Suengmok Cho and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  9. New Application of an Old Drug: Anti-Diabetic Properties of Phloroglucinol.International journal of molecular sciences · 2024
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  12. Phloroglucinol Enhances Anagen Signaling and Alleviates HJournal of microbiology and biotechnology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Cheol ParkDivision of Basic Sciences, College of Liberal Studies, Dong-Eui University, Busan 47340, Republic of Korea.
Hee-Jae ChaDepartment of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Republic of Korea.ORCID 0000-0002-6963-2685
Min Yeong KimAnti-Aging Research Center, Dong-Eui University, Busan 47340, Republic of Korea.ORCID 0000-0001-9083-8218
EunJin BangAnti-Aging Research Center, Dong-Eui University, Busan 47340, Republic of Korea.
Sung-Kwon MoonDepartment of Food and Nutrition, Chung-Ang University, Ansung 17546, Republic of Korea.
Seok Joong YunDepartment of Urology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.ORCID 0000-0001-7737-4746
Wun-Jae KimDepartment of Urology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.ORCID 0000-0002-8060-8926
Jeong Sook NohDepartment of Food Science & Nutrition, Tongmyong University, Busan 48520, Republic of Korea.
Gi-Young KimDepartment of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.ORCID 0000-0002-6878-0790
Suengmok ChoDepartment of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea.ORCID 0000-0001-5951-5832
Hyesook LeeDepartment of Convergence Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0003-3546-9370
Yung Hyun ChoiAnti-Aging Research Center, Dong-Eui University, Busan 47340, Republic of Korea.ORCID 0000-0002-1454-3124
Dong-Eui University · KRChungbuk National University · KRChung-Ang University · KRJeju National University · KRKosin University · KRPukyong National University · KRPusan National University · KRTongmyong University · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) grant funded by the Korea government 2021R1A2C200954911Basic Science Research Program through the National Research Foundation of Korea (NRF) grant funded by the Korea government 2022R1I1A1A01070768Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries 20220488
6 · The paper itself

Abstract

Phloroglucinol, a phenolic compound, is known to possess a potent antioxidant ability. However, its role in retinal cells susceptible to oxidative stress has not been well elucidated yet. Thus, the objective of this study was to evaluate whether phloroglucinol could protect against oxidative damage in cultured human retinal pigment epithelium ARPE-19 cells. For this purpose, ARPE-19 cells were stimula ted with hydrogen peroxide (H

Indexed as

apoptosisautophagyDNA damagemitochondrial ROSphloroglucinol

Identifiers

PMID36552561
PMCPMC9774705
OpenAlexW4310184958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.