Evidence map›Paper›PMID 36552520›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Site-Directed Spin Labeling EPR Spectroscopy for Determination of Albumin Structural Damage and Hypoalbuminemia in Critical COVID-19.

Ekaterina Georgieva, Yanka Karamalakova, Georgi Arabadzhiev, Vasil Atanasov, Rositsa Kostandieva, Mitko Mitev, Vanya Tsoneva, Yovcho Yovchev, Galina Nikolova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ekaterina GeorgievaDepartment of "General and Clinical Pathology, Forensic Medicine, Deontology and Dermatovenerology", Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.ORCID 0000-0003-0552-6266
Yanka KaramalakovaDepartment of "Medical Chemistry and Biochemistry", Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
Georgi ArabadzhievDepartment of "Surgery and Anesthesiology", University Hospital "Prof. Dr. St. Kirkovich", 6000 Stara Zagora, Bulgaria.
Vasil AtanasovForensic Toxicology Laboratory, Military Medical Academy, 3 "Sv. Georgi Sofiiski Str.", 1606 Sofia, Bulgaria.
Rositsa KostandievaForensic Toxicology Laboratory, Military Medical Academy, 3 "Sv. Georgi Sofiiski Str.", 1606 Sofia, Bulgaria.
Mitko MitevDepartment of "Diagnostic Imaging", University Hospital "Prof. Dr. St. Kirkovich", 6000 Stara Zagora, Bulgaria.
Vanya TsonevaDepartment of Propaedeutics of Internal Medicine and Clinical Laboratory, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
Yovcho YovchevDepartment of "Surgery and Anesthesiology", University Hospital "Prof. Dr. St. Kirkovich", 6000 Stara Zagora, Bulgaria.
Galina NikolovaDepartment of "Medical Chemistry and Biochemistry", Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.ORCID 0000-0003-2112-5753
Trakia University · BGMilitary Medical Academy · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main factors in the COVID-19 pathology, which can initiate extensive structural changes at the cellular and molecular levels, are the generation of free radicals in abnormal amounts, and oxidative stress. Under "oxidative shock" conditions, the proteins undergo various modifications that affect their function and activity, and as a result distribute malfunctioning protein derivatives in the body. Human serum albumin is a small globular protein characterized by a high overall binding capacity for neutral lipophilic and acidic dosage forms. The albumin concentration is crucial for the maintenance of plasma oncotic pressure, the transport of nutrients, amino acids, and drugs, the effectiveness of drug therapy, and the prevention of drug toxicity. Hypoalbuminemia and structural defects molecule in the protein suggest a risk of changed metabolism and increased plasma concentration of unbound drugs. Therefore, the albumin structural and functional changes accompanied by low protein levels can be a serious prerequisite for ineffective therapy, frequent complications, and high mortality in patients with SARS-CoV-2 infection. The current opinion aims the research community the application of Site-Directed Spin Labeling Electron Paramagnetic Resonance spectroscopy (SDSL-EPR) and 3-Maleimido-PROXYL radical in determining abnormalities of the albumin dynamics and protein concentrations in COVID-19 critical patients.

Indexed as

3-Maleimido-PROXYLCOVID-19hypoalbuminemiaintoxicationsite-directed spin labeling EPRspin labeling

Identifiers

PMID36552520
PMCPMC9774111
OpenAlexW4309721127

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.