Evidence map›Paper›PMID 36552517›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Predicting and Understanding the Pathology of Single Nucleotide Variants in Human

Sining Wang, Akash Jain, Noelle Alexa Novales, Audrey N Nashner, Fiona Tran, Catherine F Clarke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sining WangDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0003-4937-0566
Akash JainDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-1572-0962
Noelle Alexa NovalesDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-4903-2738
Audrey N NashnerDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Fiona TranDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Catherine F ClarkeDepartment of Chemistry & Biochemistry, The Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0002-6426-3833

Funding

Chemistry Biology Interface Training ProgramT32GM136614 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Patrick G. Harran · 2020 to 2026
$2.8M
NIGMS NIH HHS T32 GM136614
6 · The paper itself

Abstract

Coenzyme Q (CoQ) is a vital lipid that functions as an electron carrier in the mitochondrial electron transport chain and as a membrane-soluble antioxidant. Deficiencies in CoQ lead to metabolic diseases with a wide range of clinical manifestations. There are currently few treatments that can slow or stop disease progression. Primary CoQ

Indexed as

coenzyme QCOQ genesMissense3Dmitochondrial diseaseprimary CoQ deficiencysingle nucleotide variantsubiquinone

Identifiers

PMID36552517
PMCPMC9774615
OpenAlexW4309587776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.