ReviewBrain sciences2022
Cognition and Neuropsychological Changes at Altitude-A Systematic Review of Literature.
Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.Brain and behavior · 2025Pooled it
- Higher Prevalence of Cognitive Impairment in Residents of High-Altitude Regions.Oxygen (Basel, Switzerland) · 2026Article
- Personality-Related Traits and Psychological and Cognitive Outcomes Under High-Altitude Hypoxia: A Trait-Process-Outcome Framework.Behavioral sciences (Basel, Switzerland) · 2026Review
- Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.iScience · 2026Article
- Cerebral oxygenation and cognitive performance under different acute normobaric hypoxic conditions: a fNIRS study.European journal of applied physiology · 2026Article
- Graded normobaric hypoxia alters cerebral oxygenation and cognition in middle-aged adults: a single-blind counterbalanced randomized crossover trial.GeroScience · 2026Article
- High serum uric acid levels explains the negative impact of the altitude adaptation index on the brain electroencephalographic Microstate D under high-altitude hypoxic conditions.Frontiers in integrative neuroscience · 2026Article
- High-altitude hypoxia alters the developmental trajectory of working memory in Tibetan children.Frontiers in neuroscience · 2026Article
- Neural-behavioral dissociation under acute high-altitude stress: an exploratory ERP study of non-specific neural recruitment and rTMS effects.Frontiers in behavioral neuroscience · 2026Article
- Detrimental Effects of Hypoxia on Cognitive Function: Adaptations, Challenges, and Resilience in Andean Populations.Journal of racial and ethnic health disparities · 2025Article
- The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders.High altitude medicine & biology · 2025Article
- Early adaptation to high-altitude: Mood and cognitive responses at simulated 4500 m.Physiological reports · 2025Article
- Effect of altitude on the spatiotemporal signal characteristics of inversion face recognition.Scientific reports · 2025Article
- Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Preoperative hypoxic biomarkers and postoperative delirium in patients with obstructive sleep apnea.Journal of anesthesia · 2025Article
- Unraveling the complexity of cognitive impairment following high-altitude exposure: from preclinical animal models to human organoids.Frontiers in neuroscience · 2025Review
- [Identification of Differences in Brain Functions at Varied Degrees of Acclimatization to High Altitudes Based on Resting-State Electroencephalogram Signals].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Exercise performance reduction and preventive measures in highland sports.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure.Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-altitude (HA) exposure affects cognitive functions, but studies have found inconsistent results. The aim of this systematic review was to evaluate the effects of HA exposure on cognitive functions in healthy subjects. A structural overview of the applied neuropsychological tests was provided with a classification of superordinate cognitive domains. A literature search was performed using PubMed up to October 2021 according to PRISMA guidelines. Eligibility criteria included a healthy human cohort exposed to altitude in the field (at minimum 2440 m [8000 ft]) or in a hypoxic environment in a laboratory, and an assessment of cognitive domains. The literature search identified 52 studies (29 of these were field studies; altitude range: 2440 m-8848 m [8000-29,029 ft]). Researchers applied 112 different neuropsychological tests. Attentional capacity, concentration, and executive functions were the most frequently studied. In the laboratory, the ratio of altitude-induced impairments (64.7%) was twice as high compared to results showing no change or improved results (35.3%), but altitudes studied were similar in the chamber compared to field studies. In the field, the opposite results were found (66.4 % no change or improvements, 33.6% impairments). Since better acclimatization can be assumed in the field studies, the findings support the hypothesis that sufficient acclimatization has beneficial effects on cognitive functions at HA. However, it also becomes apparent that research in this area would benefit most if a consensus could be reached on a standardized framework of freely available neurocognitive tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.