P3b Amplitude and Latency in Tic Disorders: A Meta-Analysis.

Yue Yang, Hua Yang, Yao Deng, Tao Yu, Rong Luo

Abstract readReview

In one paragraph

Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yue YangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Hua YangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Yao DengDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Tao YuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Rong LuoDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Funding

National Key R&D Program of China 2021YFC1005305Sichuan Provincial Department of Science and Technology Regional Innovation Cooperation Project 2020YFQ0021

6 · The paper itself

Abstract

P3b is an event-related potential (ERP) that may be abnormal in patients with tic disorders (TD), but evidence has been inconsistent. Given the possible association between P3b and TD and the need for biomarkers for TD, the primary objective of this meta-analysis was to characterize P3b in patients with TD in comparison to healthy controls (HCs).

methodsBy searching PubMed, Embase, Web of Science, SCOPUS, Medline, and Google Scholar, we identified studies that compared P3b between TD patients and HCs. The amplitude and latency of P3b were then analyzed. Subgroup analyses were conducted to investigate the influence of different experimental factors on P3b indices.

resultOverall, 19 articles involving 388 cases and 414 controls were evaluated. There were no significant abnormalities in P3b amplitude and latency in TD patients. The P3b amplitude of the TD patients was significantly decreased during the oddball task, and the P3b amplitude of the adult TD patients was also significantly decreased.

conclusionTD patients may have an abnormal P3b compared to HCs under specified conditions.

Indexed as

ERPmeta-analysisP3btic disorders

Identifiers

PMID36552171

DOI10.3390/brainsci12121712

PMCPMC9775302

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.