Evidence map›Paper›PMID 36552153›Full record

ArticleBrain sciences2022

Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process-Multi-Cohort Multi-Modal Evidence.

Leighton Barnden, Benjamin Crouch, Richard Kwiatek, Zack Shan, Kiran Thapaliya, Donald Staines, Sandeep Bhuta, Peter Del Fante, Richard Burnet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Leighton BarndenNational Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-3976-189X
Benjamin CrouchNuclear Medicine Department, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Richard KwiatekDivision of Medical Subspecialities, Lyell McEwin Hospital, Elizabeth, SA 5112, Australia.
Zack ShanThompson Institute, University of the Sunshine Coast, Birtinya, QLD 4575, Australia.ORCID 0000-0002-9042-9278
Kiran ThapaliyaNational Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia.
Donald StainesNational Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia.
Sandeep BhutaMedical Imaging Department, Gold Coast University Hospital, Parklands Drive, QLD 4215, Australia.
Peter Del FanteThompson Institute, University of the Sunshine Coast, Birtinya, QLD 4575, Australia.
Richard BurnetEndocrinology Department, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Griffith University · AURoyal Adelaide Hospital · AUUniversity of the Sunshine Coast · AUGold Coast Hospital · AULyell McEwin Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differential axonal myelination synchronises signalling over different axon lengths. The consequences of myelination processes described at the cellular level for the regulation of myelination at the macroscopic level are unknown. We analysed multiple cohorts of myelin-sensitive brain MRI. Our aim was to (i) confirm a previous report of anti-correlation between myelination in subcortical and sensorimotor areas in healthy subjects, (ii) and thereby test our hypothesis for a regulatory interaction between them. We analysed nine image-sets across three different human cohorts using six MRI modalities. Each image-set contained healthy controls (HC) and ME/CFS subjects. Subcortical and Sensorimotor regions of interest (ROI) were optimised for the detection of anti-correlations and the same ROIs were used to test the HC in all image-sets. For each cohort, median MRI values were computed in both regions for each subject and their correlation across the cohort was computed. We confirmed

Indexed as

amygdalahippocampushumanhypothalamusinterneuronsmyelinregulationreticular activation systemsensorimotorsubcortical

Identifiers

PMID36552153
PMCPMC9776387
OpenAlexW4311151420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.