ArticleBrain sciences2022
Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.Translational psychiatry · 2025Article
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study.Quantitative imaging in medicine and surgery · 2024Article
- Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers.Neuroimage. Reports · 2024Article
- Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers.Addiction neuroscience · 2023Article
- Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Depression and alcohol misuse, frequently comorbid, are associated with altered reward processing. However, no study has examined whether and how the neural markers of reward processing are shared between depression and alcohol misuse. We studied 43 otherwise-healthy drinking adults in a monetary incentive delay task (MIDT) during fMRI. All participants were evaluated with the Alcohol Use Disorders Identification Test (AUDIT) and Beck's Depression Inventory (BDI-II) to assess the severity of drinking and depression. We performed whole brain regressions against each AUDIT and BDI-II score to investigate the neural correlates and evaluated the findings at a corrected threshold. We performed mediation analyses to examine the inter-relationships between win/loss responses, alcohol misuse, and depression. AUDIT and BDI-II scores were positively correlated across subjects. Alcohol misuse and depression shared win-related activations in frontoparietal regions and parahippocampal gyri (PHG), and right superior temporal gyri (STG), as well as loss-related activations in the right PHG and STG, and midline cerebellum. These regional activities (
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