ArticleBrain sciences2022
Altered White Matter Microstructure in Herpes Zoster and Postherpetic Neuralgia Determined by Automated Fiber Quantification.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Alterations in white matter integrity in patients with postherpetic neuralgia evidenced by peak width of skeletonized mean diffusivity analysis.The Korean journal of pain · 2026Article
- Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.The journal of headache and pain · 2026Article
- Abnormal alterations in structure-function coupling at the modular level in patients with postherpetic neuralgia.Scientific reports · 2025Article
- Altered white matter microstructural integrity in patients with postherpetic neuralgia: a combined DTI and DTI-NODDI study.Frontiers in neuroscience · 2025Article
- Central effects of short-term spinal cord stimulation in postherpetic neuralgia: a longitudinal fMRI and DTI study.Frontiers in neuroscience · 2025Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
This study aimed to explore changes in the white matter microstructure in herpes zoster (HZ) and postherpetic neuralgia (PHN) patients and to estimate the correlation of these changes with clinical data. Diffusion tensor imaging (DTI) data were collected from 33 HZ patients, 32 PHN patients, and 35 well-matched healthy controls (HCs). Subsequently, these data were analyzed by automated fiber quantification (AFQ) to accurately locate alterations in the white matter microstructure. Compared with HCs, HZ and PHN patients both showed a wide range of changes in the diffusion properties of fiber tracts. HZ patients exhibited changes primarily in the left superior longitudinal fasciculus (SLF), whereas PHN patients predominantly exhibited changes in the left inferior fronto-occipital fasciculus. The bilateral SLF and the left corticospinal tract were altered in the PHN patients compared with HZ patients. In addition, PHN patients showed a trend toward more expansive white matter alterations compared with those observed in HZ patients; additionally, in PHN patients, changes in the left cingulum cingulate were significantly correlated with changes in emotion and the duration of disease. These findings may help to elucidate the transformation from HZ to PHN and provide new ideas regarding the reasons for intractable neuropathic pain in PHN.
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