ArticleBrain sciences2022
Anodal-TDCS over Left-DLPFC Modulates Motor Cortex Excitability in Chronic Lower Back Pain.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Efficacy and safety of non-invasive brain stimulation for chronic low back pain: a systematic review and meta-analysis of randomised controlled trials.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Efficacy of transcranial electrical stimulation in the treatment of chronic nonspecific low back pain: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Transcranial direct current stimulation combined with exercise therapy for chronic low back pain: a systematic review and meta-analysis.Frontiers in human neuroscience · 2025Pooled it
- Efficacy of Transcranial Direct Current Stimulation for Chronic Non-Specific Low Back Pain: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Patient-Centered Chronic Spinal Pain Management Using Exercise and Neuromodulation: Study Protocol for a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- The Modulatory Effect of tDCS Onset Timing in Alleviating Vigilance Decrement.Brain sciences · 2025Article
- Multidimensional Effects of Manual Therapy Combined with Pain Neuroscience-Based Sensorimotor Retraining in a Patient with Chronic Neck Pain: A Case Study Using fNIRS.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Exploring the therapeutic potential of transcranial direct current stimulation for chronic low back pain: a scoping review.European journal of physical and rehabilitation medicine · 2025Article
- Assessing the Modulatory Effects of tDCS and Acupuncture on Cerebral Blood Flow in Chronic Low Back Pain Using Arterial Spin Labeling Perfusion Imaging.Brain sciences · 2025Article
- Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study.Frontiers in neuroscience · 2025Article
- Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis.Brain sciences · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain is associated with abnormal cortical excitability and increased pain intensity. Research investigating the potential for transcranial direct current stimulation (tDCS) to modulate motor cortex excitability and reduce pain in individuals with chronic lower back pain (CLBP) yield mixed results. The present randomised, placebo-controlled study examined the impact of anodal-tDCS over left-dorsolateral prefrontal cortex (left-DLPFC) on motor cortex excitability and pain in those with CLBP. Nineteen participants with CLBP (Mage = 53.16 years, SDage = 14.80 years) received 20-min of sham or anodal tDCS, twice weekly, for 4 weeks. Short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were assessed using paired-pulse Transcranial Magnetic Stimulation prior to and immediately following the tDCS intervention. Linear Mixed Models revealed no significant effect of tDCS group or time, on SICI or ICF. The interactions between tDCS group and time on SICI and ICF only approached significance. Bayesian analyses revealed the anodal-tDCS group demonstrated higher ICF and SICI following the intervention compared to the sham-tDCS group. The anodal-tDCS group also demonstrated a reduction in pain intensity and self-reported disability compared to the sham-tDCS group. These findings provide preliminary support for anodal-tDCS over left-DLPFC to modulate cortical excitability and reduce pain in CLBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.