ArticleBrain sciences2022
Multimodal Analgesia for Accelerated Rehabilitation after Total Knee Arthroplasty: A Randomized, Double-Blind, Controlled Trial on the Effect of the Co-Application of Local Infiltration Analgesia and Femoral Nerve Block Combined with Dexmedetomidine.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical utility of randomized controlled trials of regional anesthesia for lower-extremity surgery: a systematic review.Regional anesthesia and pain medicine · 2026Pooled it
- Effects of dexmedetomidine on perioperative neurocognitive disorders in elderly patients undergoing non-cardiac surgery: a scoping review.Frontiers in neuroscience · 2026Pooled it
- Efficacy of perioperative dexmedetomidine in postoperative pain and neurocognitive functions in orthopedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.International journal of surgery (London, England) · 2025Pooled it
- Induction with Ciprofol Decreases Propofol Requirement During Propofol-Remifentanil Total Intravenous Anesthesia Maintenance in Elderly Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- The effect of intraoperative dexmedetomidine versus ketamine on postoperative pain in patients receiving a femoral nerve block for total knee arthroplasty: a randomized trial.BMC anesthesiology · 2025Trial
- The role of a cryocompression device following total knee arthroplasty to assist in recovery: a randomised controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Trial
- Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy-A Randomized Controlled Trial.Drug design, development and therapy · 2023Trial
- The Effect of Dexmedetomidine on Mortality in Patients with Acute Pancreatitis: A Retrospective Propensity Score Matching Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Variability in Self-Reported Preoperative Pain Between Clinic Visits and Day of Surgery.Cureus · 2025Article
- The Minimum Clinically Important Difference of the Brief Pain Inventory During the Perioperative Period of Unicompartmental Knee Arthroplasty: A Prospective Observational Study.Journal of pain research · 2025Article
- Effects of single femoral nerve block and continuous femoral nerve block on perioperative analgesia and muscle strength in elderly patients undergoing total knee arthroplasty, a randomized clinical trial.Frontiers in surgery · 2025Article
- Research trends and frontiers in rehabilitation after total knee arthroplasty: based on bibliometric and visualization analysis.Journal of orthopaedic surgery and research · 2024Article
- Review
- Establishment and evaluation of a predictive model for length of hospital stay after total knee arthroplasty: A single-center retrospective study in China.Frontiers in surgery · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multimodal postoperative pain regimens are widely used following total knee arthroplasty (TKA). However, there are few studies on the rehabilitation of the co-application of local infiltration analgesia (LIA) and femoral nerve block (FNB) combined with dexmedetomidine (DEX) for patients undergoing TKA. This study aimed to investigate the effect of LIA plus FNB and co-application of perioperative DEX on TKA outcomes. Methods: 95 patients were randomized into two groups. Patients in group B (n = 48) received a single preoperative FNB and LIA. Patients in group A (n = 47) received FNB and LIA, as well as continuous intravenous injection of DEX starting from the induction of anesthesia to postoperative day 2. All patients were allowed patient-controlled analgesia postoperatively. Visual analog scale (VAS) scores, knee range of motion (ROM) degrees, narcotic consumption, length of hospital stay (LOS), complications, Hospital for Special Surgery (HSS) scores and Montreal Cognitive Assessment-Basic (MoCA-B) Scores were recorded. Results: In group A, the mean VAS scores at rest and during movement were lower, the amount of rescue analgesia was decreased, first time of ambulation was reduced, ROM was improved, MoCA-B Scores were increased, LOS was shorter, HSS scores were higher postoperatively compared with group B (all p < 0.05). Conclusion: Our study indicated multimodal analgesia involving a single FNB and LIA combined with DEX accelerates rehabilitation for patients undergoing TKA.
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