ArticleBrain sciences2022
STN-DBS Induces Acute Changes in β-Band Cortical Functional Connectivity in Patients with Parkinson's Disease.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Frequency- and Network-Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages.Annals of neurology · 2026Article
- Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation.Scientific data · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Subthalamic nucleus deep-brain stimulation (STN-DBS), in addition to a rapid improvement of Parkinson's disease (PD) motor symptoms, can exert fast, local, neuromodulator activity, reducing β-synchronous oscillations between STN and the motor cortex with possible antikinetic features. However, STN-DBS modulation of β-band synchronization in extramotor cortical areas has been scarcely explored. For this aim, we investigated DBS-induced short-term effects on EEG-based cortical functional connectivity (FC) in β bands in six PD patients who underwent STN-DBS within the past year. A 10 min, 64-channel EEG recording was performed twice: in DBS-OFF and 60 min after DBS activation. Seven age-matched controls performed EEG recordings as the control group. A source-reconstruction method was used to identify brain-region activity. The FC was calculated using a weighted phase-lag index in β bands. Group comparisons were made using the Wilcoxon test. The PD patients showed a widespread cortical hyperconnectivity in β bands in both DBS-OFF and -ON states compared to the controls. Moreover, switching on STN-DBS determined an acute reduction in β FC, primarily involving corticocortical links of frontal, sensorimotor and limbic lobes. We hypothesize that an increase in β-band connectivity in PD is a widespread cortical phenomenon and that STN-DBS could quickly reduce it in the cortical regions primarily involved in basal ganglia-cortical circuits.
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Registered trials
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