Evidence map›Paper›PMID 36552041›Full record

ArticleBiomedicines2022

Synbiotic Intervention Ameliorates Oxidative Stress and Gut Permeability in an In Vitro and In Vivo Model of Ethanol-Induced Intestinal Dysbiosis.

Dhara Patel, Chirayu Desai, Deepmala Singh, Virupakshi Soppina, Kirti Parwani, Farhin Patel, Palash Mandal

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Synbiotic Diet PreventsCurrent issues in molecular biology · 2026
    Article
  2. Microorganisms · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dhara PatelP. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Nadiad 388421, Gujarat, India.ORCID 0000-0002-2817-6986
Chirayu DesaiDepartment of Environmental Biotechnology, Gujarat Biotechnology University, Gandhinagar 382355, Gujarat, India.ORCID 0000-0001-8211-3575
Deepmala SinghIndian Institute of Technology, Gandhinagar 382355, Gujarat, India.
Virupakshi SoppinaIndian Institute of Technology, Gandhinagar 382355, Gujarat, India.ORCID 0000-0003-1196-7770
Kirti ParwaniP. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Nadiad 388421, Gujarat, India.
Farhin PatelP. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Nadiad 388421, Gujarat, India.
Palash MandalP. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Nadiad 388421, Gujarat, India.ORCID 0000-0001-6612-3773
Charotar University of Science and Technology · INIndian Institute of Technology Gandhinagar · INGujarat Biotechnology University

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcoholic liver disease (ALD) alters gut microbiota and tight junctions, causing bacterial components to enter the portal vein and induce oxidative stress-induced inflammation in the liver. Only corticosteroids and liver transplants are treatment options for severe alcoholic hepatitis. ALD's pathophysiology is unknown. However, acetaldehyde's toxic effects cause oxidative stress and intestinal permeability. This study investigates the influence of a synbiotic (a combination of aged garlic extract (AGE) and

Indexed as

combinational therapygut microbiomeliver diseasesynbiotic

Identifiers

PMID36552041
PMCPMC9816946
OpenAlexW4312114748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.