Evidence map›Paper›PMID 36551979›Full record

ArticleBiomedicines2022

Comparing TIMP-1 and Hsp70 in Blood and Saliva as Potential Prognostic Markers in HNSCC.

Jakob Rinecker, Romina Roesch, Sara Krippgans, Markus Nieberler, Leonhard Stark, Stefan Stangl, Bernhard Haller, Kristin Fritsche, Gabriele Multhoff, Andreas Knopf and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Salivary proteomic profile of young healthy subjects.Frontiers in molecular biosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jakob RineckerDepartment of Otorhinolaryngology, Head and Neck Surgery, Technical, School of Medicine, University of Munich, 81675 Munich, Germany.
Romina RoeschInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0001-7684-7986
Sara KrippgansDepartment of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Markus NieberlerDepartment of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Leonhard StarkDepartment of Otorhinolaryngology, Head and Neck Surgery, Technical, School of Medicine, University of Munich, 81675 Munich, Germany.
Stefan StanglDepartment of Radiation Oncology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-0439-8007
Bernhard HallerInstitute of AI and Informatics in Medicine, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-9723-393X
Kristin FritscheDepartment of Vascular and Endovascular Surgery, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Gabriele MulthoffDepartment of Radiation Oncology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-2616-3137
Andreas KnopfDepartment of Otolaryngology Head and Neck Surgery, Albert-Ludwigs-University of Freiburg, 79106 Freiburg im Breisgau, Germany.
Christof WinterInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-0253-9056
Barbara WollenbergDepartment of Otorhinolaryngology, Head and Neck Surgery, Technical, School of Medicine, University of Munich, 81675 Munich, Germany.ORCID 0000-0002-3062-459X
Markus WirthDepartment of Otorhinolaryngology, Head and Neck Surgery, Technical, School of Medicine, University of Munich, 81675 Munich, Germany.ORCID 0000-0001-7240-5363
Technical University of Munich · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Currently, there is no clinically used liquid biomarker in head and neck squamous cell carcinoma (HNSCC) patients. One reason could be the limited shedding of tumor material in early disease stages. Molecular diagnostics assessing both blood and especially saliva could potentially improve the accuracy of biomarkers. In this prospective study, two markers, tissue inhibitor of metalloprotease-1 (TIMP-1) and heat shock protein 70 (Hsp70), were analyzed in HNSCC patients. The purpose of the study was to evaluate differences between saliva and serum as sample material. Further, their prognostic and predictive value and usefulness for early detection was assessed. (2) Methods: A total of 73 HNSCC patients were prospectively monitored by collecting blood and saliva before, during, and after therapy, as well as in the follow-up period between 2018 and 2021. In total, 212 serum and 194 saliva samples were collected. A control group consisting of 40 subjects (15 patients with local infections in the head and neck area and 25 without infections) were examined as well. The collected samples were evaluated for the two proteins by using an enzyme-linked immunosorbent assay (ELISA). (3)

resultsThe TIMP-1 concentration correlated significantly in blood and saliva, whereas the Hsp70 concentration did not. Saliva TIMP-1 was significantly higher in tumor patients compared to the control group (

Indexed as

HNSCCHsp70salivaTIMP-1

Identifiers

PMID36551979
PMCPMC9775946
OpenAlexW4311372895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.