Evidence map›Paper›PMID 36551810›Full record

ReviewBiomedicines2022

Tissue Characterization in Cardiac Amyloidosis.

Veronica Musetti, Francesco Greco, Vincenzo Castiglione, Alberto Aimo, Cataldo Palmieri, Dario Genovesi, Assuero Giorgetti, Michele Emdin, Giuseppe Vergaro, Liam A McDonnell and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Serum and Tissue Light-Chains as Disease Biomarkers in AL Amyloidosis.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Present and future of endomyocardial biopsy in cardiac amyloidosis.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  9. Diagnostic challenges in cardiac amyloidosis: a case report of negative initial endomyocardial biopsy.International journal of physiology, pathophysiology and pharmacology · 2025
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Veronica MusettiHealth Science Interdisciplinary Center, Scuola Superiore di Studi Universitari, S.Anna, 56127 Pisa, Italy.
Francesco GrecoFondazione Toscana G. Monasterio, 56124 Pisa, Italy.
Vincenzo CastiglioneHealth Science Interdisciplinary Center, Scuola Superiore di Studi Universitari, S.Anna, 56127 Pisa, Italy.
Alberto AimoHealth Science Interdisciplinary Center, Scuola Superiore di Studi Universitari, S.Anna, 56127 Pisa, Italy.
Cataldo PalmieriFondazione Toscana G. Monasterio, 56124 Pisa, Italy.
Dario GenovesiFondazione Toscana G. Monasterio, 56124 Pisa, Italy.
Assuero GiorgettiFondazione Toscana G. Monasterio, 56124 Pisa, Italy.
Michele EmdinHealth Science Interdisciplinary Center, Scuola Superiore di Studi Universitari, S.Anna, 56127 Pisa, Italy.
Giuseppe VergaroHealth Science Interdisciplinary Center, Scuola Superiore di Studi Universitari, S.Anna, 56127 Pisa, Italy.
Liam A McDonnellFondazione Pisana per le Scienze, 56017 Pisa, Italy.
Angela PucciHistopathology Department, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0001-8110-4458
Scuola Superiore Sant'Anna · ITFondazione Toscana Gabriele Monasterio · ITFondazione Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac amyloidosis (CA) has long been considered a rare disease, but recent advancements in diagnostic tools have led to a reconsideration of the epidemiology of CA. Amyloid light-chain (AL) and transthyretin (ATTR) amyloidoses are the most common forms of cardiac amyloidosis. Due to the distinct treatments and the different prognoses, amyloid typing is crucial. Although a non-biopsy diagnosis can be obtained in ATTR amyloidosis when certain diagnostic criteria are fulfilled, tissue characterization still represents the gold standard for the diagnosis and typing of CA, particularly in AL amyloidosis. The present review focuses on the status of tissue characterization in cardiac amyloidosis, from histochemistry to immunohistochemistry and mass spectrometry, as well as on its future directions.

Indexed as

abdominal fat tissue biopsyAL amyloidosiscardiac amyloidosisendomyocardial biopsyhistologyimmunohistochemistrymass spectrometrytransthyretin amyloidosis

Identifiers

PMID36551810
PMCPMC9775200
OpenAlexW4310187168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.