Evidence map›Paper›PMID 36551791›Full record

ArticleBiomedicines2022

The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability.

Yuqiao Xiang, Xianjue Huang, Jessica Benitez Mendieta, Jiaqiu Wang, Phani Kumari Paritala, Thomas Lloyd, Zhiyong Li

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yuqiao XiangSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.ORCID 0000-0002-0990-1572
Xianjue HuangSchool of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Jessica Benitez MendietaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Jiaqiu WangSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Phani Kumari ParitalaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Thomas LloydDepartment of Radiology, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.
Zhiyong LiSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia.ORCID 0000-0002-6814-9165
Queensland University of Technology · AUPrincess Alexandra Hospital · AUSoutheast University · CN

Funding

Australian Research Council DP200101970Australian Research Council DP200103492National Natural Science Foundation of China 11972118National Natural Science Foundation of China 12172089National Natural Science Foundation of China 61821002
6 · The paper itself

Abstract

Degree of luminal stenosis is generally considered to be an important indicator for judging the risk of atherosclerosis burden. However, patients with the same or similar degree of stenosis may have significant differences in plaque morphology and biomechanical factors. This study investigated three patients with carotid atherosclerosis within a similar range of stenosis. Using our developed fluid-structure interaction (FSI) modelling method, this study analyzed and compared the morphological and biomechanical parameters of the three patients. Although their degrees of carotid stenosis were similar, the plaque components showed a significant difference. The distribution range of time-averaged wall shear stress (TAWSS) of patient 2 was wider than that of patient 1 and patient 3. Patient 2 also had a much smaller plaque stress compared to the other two patients. There were significant differences in TAWSS and plaque stresses among three patients. This study suggests that plaque vulnerability is not determined by a single morphological factor, but rather by the combined structure. It is necessary to transform the morphological assessment into a structural assessment of the risk of plaque rupture.

Indexed as

carotid atherosclerosisfluid–structure interactionluminal stenosisplaque vulnerabilitystructural assessment

Identifiers

PMID36551791
PMCPMC9776071
OpenAlexW4310039718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.