ArticleBiomedicines2022
Novel Mucoadhesive Wafers for Treating Local Vaginal Infections.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Fabrication and characterisation of hydroxypropyl methylcellulose/ethyl cellulose/polyvinylpyrrolidone based composite wafers as an anti-bacterial dressing: a promising approach for curcumin delivery.Scientific reports · 2026Article
- 3D printing of acetaminophen suppository and its quality and pharmacokinetic evaluation.3D printing in medicine · 2025Article
- Medicated and multifunctional composite alginate-collagen-hyaluronate based scaffolds prepared using two different crosslinking approaches show potential for healing of chronic wounds.Drug delivery and translational research · 2025Article
- Influence of Mucoadhesive Polymers on Physicochemical Features and Biocompatibility of Collagen Wafers.ACS polymers Au · 2025Article
- Development of 3D-Printed Hydrogel Disks as Standardized Platform for Evaluating Excipient Impact on Metronidazole's Antimicrobial Activity.Pharmaceutics · 2025Article
- Emerging Trends in Hydrogel for the Treatment of Vaginal Candidiasis: A Comprehensive Review.Recent advances in anti-infective drug discovery · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current vaginal formulations, such as gels and pessaries, have limitations, including poor retention. Therefore, the use of mucoadhesive formulations that adhere to the vaginal wall would allow prolonged retention and controlled drug release while reducing the required dose and the potential toxicity associated with high drug loading. The aim of the current research was to develop, characterize, and optimize freeze-dried wafers loaded with metronidazole (MTz) to treat vaginal bacterial infections. Blank (BLK) composite wafers comprising carrageenan (CARR) and sodium alginate (SA) were initially formulated; however, due to poor physico-chemical properties, Carbopol (CARB), hydroxypropylmethylcellulose (HPMC), and polyethylene glycol 200 (PEG) were included. The MTz-loaded formulations were obtained by loading optimized composite CARB:CARR- or CARB:SA-based gels (modified with HPMC and/or PEG) with 0.75% of MTz prior to freeze-drying. The physico-chemical properties were investigated using texture analysis (resistance to compressive deformation and adhesion), scanning electron microscopy (SEM), X-ray diffractometry (XRD), and attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy. Functional properties were investigated by examining the swelling, porosity, drug release, and in vitro antimicrobial activity using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.