Evidence map›Paper›PMID 36551764›Full record

ReviewBiomedicines2022

Molecular-Targeted Therapy for Tumor-Agnostic Mutations in Acute Myeloid Leukemia.

Hironori Arai, Yosuke Minami, SungGi Chi, Yoshikazu Utsu, Shinichi Masuda, Nobuyuki Aotsuka

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hironori AraiDepartment of Hematology and Oncology, Japanese Red Cross Narita Hospital, Iidacho 286-0041, Japan.ORCID 0000-0003-2026-1307
Yosuke MinamiDepartment of Hematology, National Cancer Center Hospital East, Kashiwa 277-8577, Japan.
SungGi ChiDepartment of Hematology, National Cancer Center Hospital East, Kashiwa 277-8577, Japan.ORCID 0000-0002-5725-7187
Yoshikazu UtsuDepartment of Hematology and Oncology, Japanese Red Cross Narita Hospital, Iidacho 286-0041, Japan.
Shinichi MasudaDepartment of Hematology and Oncology, Japanese Red Cross Narita Hospital, Iidacho 286-0041, Japan.
Nobuyuki AotsukaDepartment of Hematology and Oncology, Japanese Red Cross Narita Hospital, Iidacho 286-0041, Japan.
Japanese Red Cross Narita Hospital · JPNational Cancer Center Hospital East · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comprehensive genomic profiling examinations (CGPs) have recently been developed, and a variety of tumor-agnostic mutations have been detected, leading to the development of new molecular-targetable therapies across solid tumors. In addition, the elucidation of hereditary tumors, such as breast and ovarian cancer, has pioneered a new age marked by the development of new treatments and lifetime management strategies required for patients with potential or presented hereditary cancers. In acute myeloid leukemia (AML), however, few tumor-agnostic or hereditary mutations have been the focus of investigation, with associated molecular-targeted therapies remaining poorly developed. We focused on representative tumor-agnostic mutations such as the

Indexed as

acute myeloid leukemiaBRCAgenomic profilinghereditary breast and ovarian cancermolecular-targeted therapysolid tumortumor agnosticvariant

Identifiers

PMID36551764
PMCPMC9775249
OpenAlexW4309728736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.