Evidence map›Paper›PMID 36551763›Full record

ArticleBiomedicines2022

A Genome-Wide Association Study Reveals a

Anastasia Levchenko, Sergey Malov, Alexey Antonik, Anastasia Protsvetkina, Kseniya V Rybakova, Alexander Kanapin, Alexey N Yakovlev, Anna Y Nenasteva, Anton E Nikolishin, Nikolay Cherkasov and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Genes · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Anastasia LevchenkoInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0003-3509-1304
Sergey MalovInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Alexey AntonikDepartment of Geometry, Faculty of Mathematics and Mechanics, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Anastasia ProtsvetkinaInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Kseniya V RybakovaDepartment of Addictions, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg 192019, Russia.
Alexander KanapinCenter for Computational Biology, Peter the Great Saint Petersburg Polytechnic University, Saint Petersburg 195251, Russia.
Alexey N YakovlevLipetsk Regional Addiction Hospital, Lipetsk 398006, Russia.
Anna Y NenastevaMoscow Research and Practical Center for Narcology of the Department of Public Health, Moscow 109390, Russia.
Anton E NikolishinLaboratory of Molecular Genetics, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow 119034, Russia.
Nikolay CherkasovHuman Population Genetics Laboratory, Research Center for Medical Genetics, Moscow 115522, Russia.
Natalia A ChuprovaLaboratory of Molecular Genetics, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow 119034, Russia.
Anna S BlagonravovaPrivolzhsky Research Medical University, Nizhny Novgorod 603005, Russia.
Angelica V SergeevaPrivolzhsky Research Medical University, Nizhny Novgorod 603005, Russia.
Tatyana V ZhilyaevaPrivolzhsky Research Medical University, Nizhny Novgorod 603005, Russia.ORCID 0000-0001-6155-1007
Maria K DenisenkoPrivolzhsky Research Medical University, Nizhny Novgorod 603005, Russia.
Raul R GainetdinovInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Alexander O KibitovLaboratory of Molecular Genetics, Serbsky National Medical Research Center on Psychiatry and Addictions, Moscow 119034, Russia.
Evgeny M KrupitskyDepartment of Addictions, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Saint Petersburg 192019, Russia.ORCID 0000-0002-0529-4525
St Petersburg University · RUPrivolzhsky Research Medical University · RUFederal Medical Research Centre for Psychiatry and Narcology · RUSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RUFirst Pavlov State Medical University of St. Petersburg · RUPeter the Great St. Petersburg Polytechnic University · RUResearch Centre for Medical Genetics · RU

Funding

Peter the Great Saint Petersburg Polytechnic University 75-15-2021-1333Russian Foundation for Basic Research 18-015-00473АSt Petersburg University 93018770St Petersburg University M15-D3-N1
6 · The paper itself

Abstract

At least 50% of factors predisposing to alcohol dependence (AD) are genetic and women affected with this disorder present with more psychiatric comorbidities, probably indicating different genetic factors involved. We aimed to run a genome-wide association study (GWAS) followed by a bioinformatic functional annotation of associated genomic regions in patients with AD and eight related clinical measures. A genome-wide significant association of rs220677 with AD (

Indexed as

alcohol dependenceBDNFcomorbiditygene networkgenome-wide association studysex differences

Identifiers

PMID36551763
PMCPMC9775455
OpenAlexW4309728623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.