Evidence map›Paper›PMID 36551643›Full record

ArticleCancers2022

Pathogenic Variant Spectrum in Breast Cancer Risk Genes in Finnish Patients.

Anna K Nurmi, Maija Suvanto, Joe Dennis, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anna K NurmiDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0002-0479-0711
Maija SuvantoDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0001-9271-7778
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.ORCID 0000-0003-4591-1214
Kristiina AittomäkiDepartment of Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0002-2474-1378
Carl BlomqvistDepartment of Oncology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0003-3041-1938
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.ORCID 0000-0002-0916-2976
University of Helsinki · FIUniversity of Cambridge · GB

Funding

Cancer Foundation Finland N/AHelsinki University Hospital Research Fund TYH2018315Sigrid Jusélius Foundation N/A
6 · The paper itself

Abstract

Recurrent pathogenic variants have been detected in several breast and ovarian cancer (BC/OC) risk genes in the Finnish population. We conducted a gene-panel sequencing and copy number variant (CNV) analysis to define a more comprehensive spectrum of pathogenic variants in

Indexed as

BRCA1BRCA2breast cancercopy number variantgene-panel sequencingmoderate-risk genepathogenic variant

Identifiers

PMID36551643
PMCPMC9776204
OpenAlexW4311479022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.