Evidence map›Paper›PMID 36551622›Full record

ArticleCancers2022

Lipid-Nanoparticle-Mediated Delivery of Docetaxel Prodrug for Exploiting Full Potential of Gold Nanoparticles in the Treatment of Pancreatic Cancer.

Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C Tam, Sunil Krishnan, Devika B Chithrani

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Recent advances in drug delivery and targeting for the treatment of pancreatic cancer.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Abdulaziz AlhussanDepartment of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.ORCID 0000-0002-9920-2803
Nolan JacksonDepartment of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.
Sarah EatonDepartment of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.
Nancy Dos SantosDepartment of Experimental Therapeutics, British Columbia Cancer-Vancouver, Vancouver, BC V5Z IL3, Canada.
Ingrid BartaCentre for Comparative Medicine, Animal Care Services, University of British Columbia, Vancouver, BC V6T 1W5, Canada.ORCID 0000-0001-9973-5514
Josh ZaifmanIntegrated Nanotherapeutics Inc., Burnaby, BC V5G 4X4, Canada.
Sam ChenIntegrated Nanotherapeutics Inc., Burnaby, BC V5G 4X4, Canada.
Yuen Yi C TamIntegrated Nanotherapeutics Inc., Burnaby, BC V5G 4X4, Canada.
Sunil KrishnanNeurosciences, The University of Texas Health Science Center, Houston, TX 77030, USA.
Devika B ChithraniDepartment of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada.ORCID 0000-0001-5251-1388
University of Victoria · CAUniversity of British Columbia · CABC Cancer Agency · CAThe University of Texas Health Science Center at Houston · US

Funding

Kuwait Foundation for the Advancement of Sciences CB21-63SP-01NanoMedicines Innovation Network 2021-RES-SI-05National Institute of Health R01CA257241, R01DE028105, R21CA252156 and R01CA274415Natural Sciences and Engineering Research Council of Canada RGPIN-2017-04501
6 · The paper itself

Abstract

Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we explored the effect of a DTX prodrug encapsulated in lipid nanoparticles (LNP

Indexed as

docetaxelgold nanoparticleslipid nanoparticlesnanomedicinepancreatic cancer

Identifiers

PMID36551622
PMCPMC9776798
OpenAlexW4311236615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.