ArticleCancers2022
The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Impact of Additional Resection on Outcomes in Patients with Positive Proximal Margin of Perihilar Cholangiocarcinoma: A Systematic Review and Network Meta-analysis.Annals of surgical oncology · 2026Pooled it
- Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Changing concepts in perihilar cholangiocarcinoma resections and surgery.International journal of surgery (London, England) · 2026Article
- Robotic Right Hepatectomy for Peri-Hilar Cholangiocarcinoma after Liver Venous Deprivation.Annals of surgical oncology · 2026Article
- ASO Authors Reflections: Could Robotics, 3D Imaging, and Liver Venous Deprivation Potentially Redefine Surgical Standards for Perihilar Cholangiocarcinoma?Annals of surgical oncology · 2026Article
- Prognostic impact of individual resection and dissection margins in resected perihilar cholangiocarcinoma: retrospective study.BJS open · 2025Article
- Operative and Oncological Outcomes of Vascular Resection and Reconstruction for Perihilar Cholangiocarcinoma.Annals of surgical oncology · 2025Article
- Prognostic implications of morphological subtypes in a surgical cohort of perihilar cholangiocarcinoma: the overriding impact of nodal status.International journal of clinical oncology · 2025Article
- Failure-to-rescue as a determinant of overall survival following resection for perihilar cholangiocarcinoma.JHEP reports : innovation in hepatology · 2025Article
- Tumor invasion loci in resected margins of perihilar cholangiocarcinoma and their impact on survival: a retrospective 13-year longitudinal cohort study.World journal of surgical oncology · 2025Article
- Development and validation of a machine learning-based nomogram for survival prediction of patients with hilar cholangiocarcinoma after curative-intent resection.Scientific reports · 2025Article
- Feasibility and safety of robotic radical resection for hilar cholangiocarcinoma in highly selected patients: A systematic review and meta-analysis with meta-regression.Annals of hepato-biliary-pancreatic surgery · 2025Review
- Article
- Current Perspectives in Liver Transplantation for Perihilar Cholangiocarcinoma.Current oncology (Toronto, Ont.) · 2023Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evaluation of surgical margins in resected perihilar cholangiocarcinoma (PHCC) remains a challenging issue. Both ductal (DM) and radial margin (RM) should be considered to define true radical resections (R0). Although DM status is routinely described in pathological reports, RM status is often overlooked. Therefore, the frequency of true R0 and its impact on survival might be biased.
objectiveTo improve the evaluation of RM status and investigate the impact of true R0 on survival.
methodsFrom 2014 to 2020, 90 patients underwent curative surgery for PHCC at Verona University Hospital, Verona, Italy. Both DM (proximal and distal biliary margin) and RM (hepatic, periductal, and vascular margin) status were evaluated by expert hepatobiliary pathologists. Patients with lymph-node metastases or positive surgical margins (R1) were candidates for adjuvant treatment. Clinicopathological and survival data were retrieved from an institutional database.
resultsTrue R0 were 46% (41) and overall R1 were 54% (49). RM positivity resulted in being higher than DM positivity (48% versus 27%). Overall survival was better in patients with true R0 than in patients with R1 (median survival time: 53 vs. 28 months;
conclusionExcellent survival was observed in true R0 patients. The improved evaluation of RM status is mandatory to properly stratify prognosis and select patients for adjuvant treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.