Evidence map›Paper›PMID 36551527›Full record

ArticleCancers2022

Dosimetric Benefit of Adaptive Magnetic Resonance-Guided Stereotactic Body Radiotherapy of Liver Metastases.

Fabian Weykamp, Efthimios Katsigiannopulos, Lars Piskorski, Sebastian Regnery, Philipp Hoegen, Jonas Ristau, C Katharina Renkamp, Jakob Liermann, Tobias Forster, Kristin Lang and 6 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fabian WeykampDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Efthimios KatsigiannopulosDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Lars PiskorskiDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Sebastian RegneryDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Philipp HoegenDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jonas RistauDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-5584-6909
C Katharina RenkampDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jakob LiermannDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Tobias ForsterDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Kristin LangDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Laila KönigDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Carolin RippkeDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Carolin BucheleDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Sebastian KlüterDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0003-3139-3444
Juliane Hörner-RieberDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

Funding

Deutsche Forschungsgemeinschaft DE-614/16-1
6 · The paper itself

Abstract

(1) Background: To assess dosimetry benefits of stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) of liver metastases. (2) Methods: This is a subgroup analysis of an ongoing prospective registry including patients with liver metastases. Patients were treated at the MRIdian Linac between February 2020 and April 2022. The baseline plan was recalculated based on the updated anatomy of the day to generate the predicted plan. This predicted plan could then be re-optimized to create an adapted plan. (3) Results: Twenty-three patients received 30 SMART treatment series of in total 36 liver metastases. Most common primary tumors were colorectal- and pancreatic carcinoma (26.1% respectively). Most frequent fractionation scheme (46.6%) was 50 Gy in five fractions. The adapted plan was significantly superior compared to the predicted plan in regard to planning-target-volume (PTV) coverage, PTV overdosing, and organs-at-risk (OAR) dose constraints violations (91.5 vs. 38.0%, 6 vs. 19% and 0.6 vs. 10.0%; each p < 0.001). Plan adaptation significantly increased median BEDD95 by 3.2 Gy (p < 0.001). Mean total duration of SMART was 72.4 min. (4) Conclusions: SMART offers individualized ablative irradiation of liver metastases tailored to the daily anatomy with significant superior tumor coverage and improved sparing of OAR.

Indexed as

liver metastasesMR-guidedstereotactic body radiotherapy (SBRT)stereotactic MR-guided adaptive radiotherapy

Identifiers

PMID36551527
PMCPMC9775484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.