ArticleAntibiotics (Basel, Switzerland)2022
Cytotoxicity and Antibacterial Efficacy of AgCu and AgFe NanoAlloys: A Comparative Study.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Low-frequency ultrasound-assisted application of Ag/Cu nanocomposites as a promising strategy for the treatment of purulent wounds.Discover nano · 2026Article
- Advances in Antimicrobial Applications of Ag, Cu, and AgCu Nanoparticle-Doped Polymeric Composite Materials: A Comprehensive Review.ACS nano · 2025Review
- Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids.Biomimetics (Basel, Switzerland) · 2025Article
- Green synthesis of Ag-Fe bimetallic nanoparticles using fungal filtrates: unlocking multifunctional medical and environmental applications.RSC advances · 2025Article
- AaeAP2a, a scorpion-derived antimicrobial peptide, combats carbapenem-resistantFrontiers in microbiology · 2025Article
- Enhanced Antimicrobial Activity of AgCu Nanoparticles: The Role of Particle Size and Alloy Composition.Molecules (Basel, Switzerland) · 2024Article
- The Enhanced Durability of AgCu Nanoparticle Coatings for Antibacterial Nonwoven Air Conditioner Filters.Molecules (Basel, Switzerland) · 2023Article
- Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Ag nanoparticles (NPs) have been widely applied in daily life and in biomedical and industrial fields, there is a demand for Ag-based bimetallic nanoalloys (NAs), such as AgCu and AgFe, due to their enhanced antibacterial efficacy and reduced Ag consumption. In this work, we present a comparison study on the antibacterial efficacy and cytotoxicity rates of Ag NPs and AgCu and AgFe NAs to L929 mouse fibroblast cells using the CCK-8 technique based on the relative cell viability. The concept of the minimum death concentration (MDC) is introduced to estimate the cytotoxicity to the cells. It is found that the minimum inhibitory concentrations (MICs) of the NPs against E. coli and S. aureus decrease with the addition of both Cu and Fe. There is a strong correlation between the MDC and MIC, implying that the mechanisms of both antibacterial efficacy and cytotoxicity are similar. The enhanced antibacterial efficacy to bacteria and cytotoxicity toward the cell are attributed to Ag+ release. The following order is found for both the MIC and MDC: AgFe < AgCu < Ag NPs. However, there is no cytotoxicity to the L929 cells for AgFe and AgCu NAs at their MIC Ag concentrations against S. aureus.
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Registered trials
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