ArticleAntibiotics (Basel, Switzerland)2022
Epidemiology and Economic Outcomes Associated with Timely versus Delayed Receipt of Appropriate Antibiotic Therapy among US Patients Hospitalized for Native Septic Arthritis: A Retrospective Cohort Study.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Efficacy of a six-portal arthroscopic technique in managing acute septic arthritis of the native knee: A retrospective cohort study in a tertiary orthopaedic department.Journal of experimental orthopaedics · 2026Article
- Optimizing species identification after antimicrobial pretreatment in Enterobacterales: a prospective cohort study.BMC microbiology · 2026Article
- Bone and Joint Infections in Tropical Settings: High Prevalence of Gram-Negative Bacilli and Implications for Empirical Therapy.Open forum infectious diseases · 2026Article
- The Clinical and Economic Value of Incorporating Monocyte Distribution Width Testing in the Detection of Occult Sepsis.Journal of health economics and outcomes research · 2026Article
- Septic arthritis score (SAS) - a novel clinical prediction model for the probability of septic arthritis in the adult native knee.BMC infectious diseases · 2025Article
- Prospective evaluation of real-world performance and clinical impact of the Biofire FilmArray joint infection panel.Microbiology spectrum · 2025Article
- Arthroscopy or arthrotomy for native knee septic arthritis: A systematic review.Journal of experimental orthopaedics · 2024Article
- Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study.Journal of bone and joint infection · 2024Article
- Multicenter evaluation of the BIOFIRE Joint Infection Panel for the detection of bacteria, yeast, and AMR genes in synovial fluid samples.Journal of clinical microbiology · 2023Article
- Performance and Hypothetical Impact on Joint Infection Management of the BioFire Joint Infection Panel: a Retrospective Analysis.Journal of clinical microbiology · 2023Article
- Rapid and Accurate Diagnosis of Joint Infections: Potential Clinical Effect of the BioFire Joint Infection Panel.JB & JS open accessArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Timely administration of appropriate antibiotic therapy is associated with better patient outcomes and lower costs of care compared to delayed appropriate therapy, yet initial treatment is often empiric since causal pathogens are typically unknown upon presentation. The challenge for clinicians is balancing selection of adequate coverage treatment regimens, adherence to antimicrobial stewardship principles to deter resistance, and financial constraints. This retrospective cohort study aimed to assess the magnitude and impact of delayed appropriate antibiotic therapy among patients hospitalized with septic arthritis (SA) in the U.S. from 2017 to 2019 using healthcare encounter data. Timely appropriate therapy was defined as the receipt of antibiotic(s) with in vitro activity against identified pathogens within two days of admission; all other patients were assumed to have received delayed appropriate therapy. Of the 517 patients admitted to hospital for SA who met all selection criteria, 26 (5.0%) received delayed appropriate therapy. In inverse-probability-treatment-weighting-adjusted analyses, the receipt of delayed appropriate therapy was associated with an additional 1.1 days of antibiotic therapy, 1.4 days in length of stay, and $3531 in hospital costs (all vs. timely appropriate therapy; all
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