Evidence map›Paper›PMID 36551338›Full record

ReviewAntibiotics (Basel, Switzerland)2022

Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review.

Bharat Kumar Reddy Sanapalli, Akram Ashames, Dilep Kumar Sigalapalli, Afzal B Shaik, Richie R Bhandare, Vidyasrilekha Yele

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Light-Promoted C-H/C-H Coupling of Imidazo[1,2-Molecules (Basel, Switzerland) · 2026
    Article
  2. IMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Synthesis of imidazopyridinesRSC advances · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Synthesis and antimycotic activity of new derivatives of imidazo[1,2-Beilstein journal of organic chemistry · 2024
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bharat Kumar Reddy SanapalliDepartment of Pharmacology, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur 303121, Rajasthan, India.ORCID 0000-0002-9162-5553
Akram AshamesCollege of Pharmacy & Health Sciences, Ajman University, Ajman P.O. Box 340, United Arab Emirates.ORCID 0000-0003-3124-8802
Dilep Kumar SigalapalliDepartment of Pharmaceutical Chemistry, Vignan Pharmacy College, Jawaharlal Nehru Technological University, Vadlamudi 522213, Andhra Pradesh, India.ORCID 0000-0002-7286-0128
Afzal B ShaikSt. Mary's College of Pharmacy, St. Mary's Group of Institutions Guntur, Jawaharlal Nehru Technological University Kakinada, Guntur 522212, Andhra Pradesh, India.ORCID 0000-0002-9036-1963
Richie R BhandareCollege of Pharmacy & Health Sciences, Ajman University, Ajman P.O. Box 340, United Arab Emirates.
Vidyasrilekha YeleDepartment of Pharmaceutical Chemistry, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur 303121, Rajasthan, India.ORCID 0000-0001-8298-1161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines (IZPs) are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Only one IZP, i.e., rifaximin, is available on the market as an antibiotic. In this review, the authors highlight strategies for preparing other IZPs. A particular focus is on the antibacterial profile and structure-activity relationship (SAR) of various synthesized IZP derivatives. This research provides a foundation for the tuning of available compounds to create novel, potent antibacterial agents with fewer side effects.

Indexed as

antibacterial activityimidazopyridinemulti-drug resistanceSAR studiessynthetic approaches

Identifiers

PMID36551338
PMCPMC9774741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.