Evidence map›Paper›PMID 36551331›Full record

ArticleBiomolecules2022

Novel Selective and Low-Toxic Inhibitor of

Vitor Partite Moreira, Michele Ferreira da Silva Mela, Luana Ribeiro Dos Anjos, Leonardo Figueiredo Saraiva, Angela M Arenas Velásquez, Predrag Kalaba, Anna Fabisiková, Leandro da Costa Clementino, Mohammed Aufy, Christian Studenik and 10 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. BrazilianToxins · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Vitor Partite MoreiraFine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-080, Brazil.
Michele Ferreira da Silva MelaSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.ORCID 0000-0002-3587-351X
Luana Ribeiro Dos AnjosFine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-080, Brazil.ORCID 0000-0002-2487-6176
Leonardo Figueiredo SaraivaLaboratory of Luminescence in Materials and Sensors, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-560, Brazil.ORCID 0000-0002-1963-9854
Angela M Arenas VelásquezSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.
Predrag KalabaDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Josef Holaubek Platz 2, UZAII, 1090 Vienna, Austria.
Anna FabisikováMass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.
Leandro da Costa ClementinoSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.
Mohammed AufyDepartment of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef Holaubek Platz 2, UZAII (2D 259), 1090 Vienna, Austria.ORCID 0000-0002-6693-4530
Christian StudenikDepartment of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef Holaubek Platz 2, UZAII (2D 259), 1090 Vienna, Austria.ORCID 0000-0002-0910-4573
Natalie GajicCentre for X-ray Structure Analysis, Faculty of Chemistry, University of Vienna, Währinger Straße 40-42, 1090 Vienna, Austria.
Alexander Prado-RollerCentre for X-ray Structure Analysis, Faculty of Chemistry, University of Vienna, Währinger Straße 40-42, 1090 Vienna, Austria.ORCID 0000-0002-3719-801X
Alvicler MagalhãesDepartment of Organic Chemistry, Chemistry School, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil.ORCID 0000-0001-7439-8400
Martin ZehlMass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.ORCID 0000-0001-9685-0373
Ingrid Delbone FigueiredoSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.
Amanda Martins BavieraSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.ORCID 0000-0003-0987-5295
Eduardo Maffud CilliDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, Brazil.ORCID 0000-0002-4767-0904
Marcia A S GraminhaSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil.ORCID 0000-0001-7280-3775
Gert LubecDepartment of Neuroproteomics, Paracelsus Medical University, 5020 Salzburg, Austria.
Eduardo R Perez GonzalezFine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-080, Brazil.ORCID 0000-0003-1348-8554
Universidade Estadual Paulista (Unesp) · BRUniversity of Vienna · ATParacelsus Medical University · ATUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus

Indexed as

Cysteine ProteasesLeishmania majorLeishmaniasisAnimalsGuanidineMammalsMiceVirulenceCysteine ProteasesGuanidineguanidinesLeishmania cysteine protease inhibitionleishmanicidal activitymolecular dockingX-ray and NMR conformational study

Identifiers

PMID36551331
PMCPMC9775234
OpenAlexW4313237697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.