Evidence map›Paper›PMID 36551329›Full record

ArticleBiomolecules2022

Phenylbenzohydrazides Obtained from Isatoic Anhydride Present Anti-Inflammatory Activity In Vivo and In Vitro.

João Pedro Barros Paiva, Millena Santos Cordeiro, Patricia Ribeiro Carvalho França, Luiz Octavio Pereira Branco, Isabela Souza Santos, Nanashara Figueiredo Reis, Patrick Pedro Pimentel, Thais Biondino Sardella Giorno, Evanoel Crizanto Lima, Patricia Dias Fernandes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Evaluation of phenyl hydrazide-based compounds as myeloperoxidase inhibitors.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

João Pedro Barros PaivaLaboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.ORCID 0000-0001-5663-000X
Millena Santos CordeiroLaboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
Patricia Ribeiro Carvalho FrançaLaboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.ORCID 0000-0001-7661-7726
Luiz Octavio Pereira BrancoLaboratório de Catálise e Síntese de Substâncias Bioativas, CM UFRJ-Macaé, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27971-525 Macaé, Brazil.
Isabela Souza SantosLaboratório de Catálise e Síntese de Substâncias Bioativas, CM UFRJ-Macaé, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27971-525 Macaé, Brazil.
Nanashara Figueiredo ReisLaboratório de Catálise e Síntese de Substâncias Bioativas, CM UFRJ-Macaé, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27971-525 Macaé, Brazil.
Patrick Pedro PimentelLaboratório de Catálise e Síntese de Substâncias Bioativas, CM UFRJ-Macaé, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27971-525 Macaé, Brazil.
Thais Biondino Sardella GiornoLaboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
Evanoel Crizanto LimaLaboratório de Catálise e Síntese de Substâncias Bioativas, CM UFRJ-Macaé, Instituto Multidisciplinar de Química, Universidade Federal do Rio de Janeiro, 27971-525 Macaé, Brazil.ORCID 0000-0002-3655-7658
Patricia Dias FernandesLaboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.ORCID 0000-0001-6870-6745
Universidade Federal do Rio de Janeiro · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior fellowship to J.P.B.P. and M.S.C.Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.001837/2015Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) E-26/110.998/2013Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) SEI-260003/001182/2020Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) SEI-260003/003464/2022Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) SEI-260003/012984/2021National Council for Scientific and Technological Development 308557/2021-2
6 · The paper itself

Abstract

backgroundDespite the existence of a wide variety of anti-inflammatory drugs, the vast majority are classified as steroidal or non-steroidal. Both classes present a variety of side effects that limit usage. Thus, the search for new molecules with anti-inflammatory potential is still important.

methodsFive phenylbenzohydrazides were synthetized and evaluated in pre-clinical models of acute inflammation in vivo and in vitro.

resultsThe new substances (INL-06, -07, -10, and -11), as well as AISCT, significantly reduced cell migration induced by carrageenan. It was also observed that all INLs inhibited protein extravasation as well as cytokines (IL-6, IL-1β, and TNF-α) and nitric oxide (NO) production. The INL-11 was demonstrated to be the most potent, since the inhibition observed in several parameters was significant even when compared with dexamethasone. In vitro INLs also reduced cytokines and NO production and inducible nitric oxide (iNOS) enzyme activity. The INL-11 was the most effective in reducing cell migration in vitro.

conclusionsOur data suggest that these substances are suitable for further development into a new series of compounds that could lead to new hits and future drug prototypes for anti-inflammatory conditions.

Indexed as

Anti-Inflammatory AgentsNitric OxideCarrageenanCytokinesHumansInflammationOxazinesAnti-Inflammatory AgentsCarrageenanCytokinesisatoic anhydrideNitric OxideOxazinesanti-inflammatory substancecarrageenan-induced inflammationinflammationisatoic anhydridenitric oxidephenylbenzohydrazides

Identifiers

PMID36551329
PMCPMC9776041
OpenAlexW4311884369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.