Evidence map›Paper›PMID 36551295›Full record

ArticleBiomolecules2022

Chronic Bedridden Condition Is Reflected by Substantial Changes in Plasma Inflammatory Profile.

Roberta Magliozzi, Anna Pedrinolla, Stefania Rossi, Anna Maria Stabile, Elisa Danese, Giuseppe Lippi, Federico Schena, Massimiliano Calabrese, Massimo Venturelli Venturelli

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Roberta MagliozziDepartment of Neurological and Movement Sciences, Neurology Section, University of Verona, 37100 Verona, Italy.ORCID 0000-0001-8284-7763
Anna PedrinollaDepartment of Cellular, Computational, and Integrative Biology, CIBIO, University of Trento, 38123 Trento, Italy.ORCID 0000-0001-8888-619X
Stefania RossiDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Anna Maria StabileDepartment of Surgery and Biomedical Sciences, Section of Human Anatomy, Clinical and Forensic, School of Medicine, 06132 Perugia, Italy.ORCID 0000-0003-1047-4210
Elisa DaneseDepartment of Life and Reproduction Sciences, Laboratory of Clinical Biochemistry, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-2454-0410
Giuseppe LippiDepartment of Life and Reproduction Sciences, Laboratory of Clinical Biochemistry, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9523-9054
Federico SchenaDepartment of Neuroscience, Biomedicine, and Movement Science, Movement Science Section, University of Verona, 37131 Verona, Italy.
Massimiliano CalabreseDepartment of Neurological and Movement Sciences, Neurology Section, University of Verona, 37100 Verona, Italy.ORCID 0000-0002-3362-7403
Massimo Venturelli VenturelliDepartment of Neuroscience, Biomedicine, and Movement Science, Movement Science Section, University of Verona, 37131 Verona, Italy.ORCID 0000-0002-2469-8787
University of Verona · ITIstituto Superiore di Sanità · ITUniversity of Perugia · ITUniversity of Trento · IT

Funding

Cassa di Risparmio Perugia 2019.0326Ministry of Education, Universities and Research PRIN 2017RS5M4
6 · The paper itself

Abstract

Absent or reduced physical activity and spontaneous movement over days, weeks, or even years may lead to problems in almost every major organ/system in the human body. In this study, we investigated whether the dysregulation and alteration of plasma protein inflammatory profiling can stratify chronic bedridden conditions observed in 22 elderly chronic bedridden (CBR) individuals with respect to 11 age-matched active (OLD) controls. By using a combination of immune-assay multiplex techniques, a complex of 27 inflammatory mediators was assessed in the plasma collected from the two groups. A specific plasma protein signature is indeed able to distinguish IPO individuals from age-matched OLD controls; while significantly (

Indexed as

Bedridden PersonsInflammation MediatorsInterleukin-12AgedBiomarkersChronic DiseaseCytokinesHumansPlasmaBiomarkersCytokinesInflammation MediatorsInterleukin-12chronic bedridden conditioninflammatory changesplasma biomarkers

Identifiers

PMID36551295
PMCPMC9775060
OpenAlexW4311377405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.