Evidence map›Paper›PMID 36551208›Full record

ArticleBiomolecules2022

Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks.

Qing Ye, Nancy Lan Guo

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qing YeWest Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.
Nancy Lan GuoWest Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-8050-6268
West Virginia University · US

Funding

THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI HARNER, JAMES · 2001 to 2010
$22.8M
A Novel Computational Framework for Individualized Clinical Decision-MakingR01LM009500 · NLM · WEST VIRGINIA UNIVERSITY · PI GUO, NANCY LAN · 2008 to 2010
$987k
A Novel Computational Framework for individualized clinical decision-makingR56LM009500 · NLM · WEST VIRGINIA UNIVERSITY · PI GUO, NANCY LAN · 2012 to 2013
$499k
ARRA NIH HHSNational Institute of Health P20RR16440NCRR NIH HHS P20 RR016440NLM NIH HHS R01 LM009500NLM NIH HHS R56 LM009500
6 · The paper itself

Abstract

There are currently no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). Novel therapeutic targets are needed to improve NSCLC survival outcomes. This study systematically evaluated the association between genome-scale regulatory network centralities and NSCLC tumorigenesis, proliferation, and survival in early-stage NSCLC patients. Boolean implication networks were used to construct multimodal networks using patient DNA copy number variation, mRNA, and protein expression profiles.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsBiomarkers, TumorCarcinogenesisDNA Copy Number VariationsGene Regulatory NetworksHumansBiomarkers, TumorbiomarkersCRISPR-Cas9hub genesmulti-omics networksnon-small cell lung cancerpatient survivalproliferationRNAitherapeutic targets

Identifiers

PMID36551208
PMCPMC9776006
OpenAlexW4311002174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.