ReviewBiomolecules2022
Zinc in Human Health and Infectious Diseases.
Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 121 citations in OpenAlex.
- From Antibacterial to Antifungal: Structure, Safety, and Serum Albumin Binding of Zn(II)-Nalidixate Complexes with Phenanthroline and Bipyridine.Biological trace element research · 2026Article
- The association between anthropometric failure and zinc deficiency among preschool-age children in rural Sidama region, Ethiopia: a community-based cross-sectional study.BMC nutrition · 2026Article
- The hazards of metal exposure mediated by crops to human health from perspective of environmental health and control strategies.iScience · 2026Review
- Immunomodulatory and Anti-Inflammatory Effects of Phycocyanin Oligopeptide Combined with Selenium and Zinc in LPS-Induced Mice.Biomedicines · 2026Article
- Biomimetic bone-like regeneration potentiality and strength development of Mg-Zn-Ca alloys for maxillofacial application.BMC oral health · 2026Article
- Comparative exposure and risk assessment of heavy metals, nutrients, and organochlorine pesticides in cow and plant-based milks.Scientific reports · 2026Article
- Changes in Prooxidant and Antioxidant-Related Trace Element Levels During Helicobacter pylori Eradication Therapy.Biological trace element research · 2026Article
- Polyphenol mediated zinc-oxygen synergistic hydrogel remodels senescent microenvironment for periodontal tissue regeneration.Nature communications · 2026Article
- Phytochemical Characterization and Biological Assessment ofAntioxidants (Basel, Switzerland) · 2026Article
- The Role of Zinc Against Bacterial Infections in Neonates, Children, and Adults: A Scoping Review from the Available Evidence of Randomized Controlled Trials About Zinc Supplementation to New Research Opportunities.Antibiotics (Basel, Switzerland) · 2026Review
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study.Frontiers in nutrition · 2026Article
- Micronutrient status and growth outcomes in children with cow's milk allergy: beyond elimination diets.Frontiers in nutrition · 2026Review
- Low zinc status and long-term risk of incident sepsis in patients with type 2 diabetes: a multicenter cohort study.Frontiers in nutrition · 2026Article
- Beyond VDR: Vitamin D Metabolism Genes in Tuberculosis Susceptibility, Immune Response and Implications for Diabetes Mellitus.Infection and drug resistance · 2026Review
- Nutritional composition, sensory acceptability and shelf-life evaluation of wheat-corn chaff composite cake.Frontiers in nutrition · 2026Article
- Identification of the Nicotianamine synthase (NAS) gene family in wheat (Triticum aestivum L.) and the role of its member TaNAS4-A in Zn and Fe transport.Functional & integrative genomics · 2025Article
- Beyond Calories: Addressing Micronutrient Deficiencies in the World's Most Vulnerable Communities-A Review.Nutrients · 2025Review
- Zinc as a Modulator of miRNA Signaling in Obesity.Nutrients · 2025Review
- ZIP10 as a potential therapeutic target in acute myeloid leukaemia.British journal of haematology · 2025Article
- Highly Sensitive and Selective Recognition of ZnJournal of fluorescence · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last few decades, the micronutrient zinc has proven to be an important metal ion for a well-functioning immune system, and thus also for a suitable immune defense. Nowadays, it is known that the main cause of zinc deficiency is malnutrition. In particular, vulnerable populations, such as the elderly in Western countries and children in developing countries, are often affected. However, sufficient zinc intake and homeostasis is essential for a healthy life, as it is known that zinc deficiency is associated with a multitude of immune disorders such as metabolic and chronic diseases, as well as infectious diseases such as respiratory infections, malaria, HIV, or tuberculosis. Moreover, the modulation of the proinflammatory immune response and oxidative stress is well described. The anti-inflammatory and antioxidant properties of zinc have been known for a long time, but are not comprehensively researched and understood yet. Therefore, this review highlights the current molecular mechanisms underlying the development of a pro-/ and anti-inflammatory immune response as a result of zinc deficiency and zinc supplementation. Additionally, we emphasize the potential of zinc as a preventive and therapeutic agent, alone or in combination with other strategies, that could ameliorate infectious diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.