Evidence map›Paper›PMID 36551162›Full record

ArticleBiomolecules2022

Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake.

Shawna L McMillin, Parker L Evans, William M Taylor, Luke A Weyrauch, Tyler J Sermersheim, Steven S Welc, Monique R Heitmeier, Richard C Hresko, Paul W Hruz, Francoise Koumanov and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Shawna L McMillinDepartments of Kinesiology, Biochemistry & Molecular Biology, and Physiology, Brody School of Medicine, East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC 27858, USA.ORCID 0000-0002-2229-8747
Parker L EvansDepartments of Kinesiology, Biochemistry & Molecular Biology, and Physiology, Brody School of Medicine, East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC 27858, USA.
William M TaylorDepartments of Kinesiology, Biochemistry & Molecular Biology, and Physiology, Brody School of Medicine, East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC 27858, USA.
Luke A WeyrauchDepartments of Kinesiology, Biochemistry & Molecular Biology, and Physiology, Brody School of Medicine, East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC 27858, USA.
Tyler J SermersheimDepartment of Anatomy, Cell Biology & Physiology, and Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Steven S WelcDepartment of Anatomy, Cell Biology & Physiology, and Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2353-0325
Monique R HeitmeierDepartments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Richard C HreskoDepartments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Paul W HruzDepartments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63130, USA.ORCID 0000-0002-1478-3355
Francoise KoumanovDepartment of Health, University of Bath, Bath BA2 7AY, UK.ORCID 0000-0002-9029-3390
Geoffrey D HolmanDepartment of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
E Dale AbelFraternal Order of Eagles Diabetes Research Center, Division of Endocrinology & Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-5290-0738
Carol A WitczakDepartments of Kinesiology, Biochemistry & Molecular Biology, and Physiology, Brody School of Medicine, East Carolina Diabetes & Obesity Institute, East Carolina University, Greenville, NC 27858, USA.
East Carolina University · USWashington University in St. Louis · USIndiana University School of MedicineUniversity of Bath · GBUniversity of Iowa · US

Funding

Calmodulin Kinases and Control of Skeletal Muscle Glucose MetabolismR01DK103562 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI WITCZAK, CAROL ANN · 2015 to 2019
$1.7M
Molecular Mechanisms Regulating Functional Overload Stimulated Glucose Uptake in Skeletal MuscleF31DK119080 · NIDDK · EAST CAROLINA UNIVERSITY · PI MCMILLIN, SHAWNA · 2018 to 2019
$66k
American College of Sports Medicine 18-00636Children's Discovery Institute MI-II-2017-593Medical Research Council MR/J003417/1Medical Research Council MR/P002927/1Muscular Dystrophy Association 603201NIDDK NIH HHS F31 DK119080NIDDK NIH HHS R01 DK103562
6 · The paper itself

Abstract

Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 levels. The primary objective of this study was to determine if GLUT1 is necessary for basal or overload-stimulated muscle glucose uptake. Muscle-specific GLUT1 knockout (mGLUT1KO) mice were generated and examined for changes in body weight, body composition, metabolism, systemic glucose regulation, muscle glucose transporters, and muscle [

Indexed as

GlucoseGlucose Transporter Type 1Muscle, SkeletalAnimalsBody WeightGlucose Transporter Type 4HEK293 CellsHumansInsulinMiceMice, KnockoutGlucoseGlucose Transporter Type 1Glucose Transporter Type 4InsulinSlc2a1 protein, mouseBAY-876bio-LC-ATB-BGPAglucose transportGLUT1mechanical overloadskeletal muscleSLC2A1synergist ablation

Identifiers

PMID36551162
PMCPMC9776291
OpenAlexW4309722971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.