Evidence map›Paper›PMID 36551159›Full record

ArticleBiomolecules2022

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute

Megan Osbourn, Aoife M Rodgers, Alice V Dubois, Donna M Small, Fiachra Humphries, Nezira Delagic, Paul N Moynagh, Sinéad Weldon, Clifford C Taggart, Rebecca J Ingram

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  11. Biologically Relevant Murine Models of ChronicPathogens (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Megan OsbournWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.
Aoife M RodgersDepartment of Biology, The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, W23 F2H6 Maynooth, Ireland.
Alice V DuboisWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.
Donna M SmallThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7BL, UK.
Fiachra HumphriesDepartment of Biology, The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, W23 F2H6 Maynooth, Ireland.
Nezira DelagicDepartment of Biology, The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, W23 F2H6 Maynooth, Ireland.
Paul N MoynaghWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.
Sinéad WeldonWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.ORCID 0000-0001-5628-6624
Clifford C TaggartWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.
Rebecca J IngramWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.ORCID 0000-0003-1832-2457
Queen's University Belfast · GBNational University of Ireland, Maynooth · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secretory leucoprotease inhibitor (SLPI) has multifaceted functions, including inhibition of protease activity, antimicrobial functions, and anti-inflammatory properties. In this study, we show that SLPI plays a role in controlling pulmonary

Indexed as

InflammationPseudomonas InfectionsSecretory Leukocyte Peptidase InhibitorAnimalsHumansLipopolysaccharidesMiceRecombinant ProteinsLipopolysaccharidesRecombinant ProteinsSecretory Leukocyte Peptidase InhibitorSLPI protein, humanSlpi protein, mouseinfectioninflammationPseudomonassecretory leucoprotease inhibitorSLPI

Identifiers

PMID36551159
PMCPMC9776001
OpenAlexW4309722182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.