Evidence map›Paper›PMID 36551145›Full record

ArticleBiosensors2022

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis.

Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaoyan LiuSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Qiangqiang YangSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Yanan SuiSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Qiaoli YueSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Shuqing YanSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Chuan LiSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Min HongSchool of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.ORCID 0000-0001-8406-0323
Liaocheng University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA was designed to monitor and down-regulate intracellular GPX4 mRNA using fluorescence imaging in situ and using anti-sense technology. The results revealed that there was a marked difference for the expression of GPX4 mRNA in different cell lines, and the survival rate of cancer cells was not significantly effected when the relative mRNA and protein expression levels of GPX4 was down-regulated by AuNF probes. However, when co-treated with AuNF probes, the low expression of GPX4 strengthened erastin-induced ferroptosis, and this synergy showed a better effect on inhibiting the proliferation of cancer cells.

Indexed as

FerroptosisCell LineGlutathione PeroxidasePiperazineserastinGlutathione PeroxidasePiperazinesAuNF probeferroptosisGPX4 mRNA

Identifiers

PMID36551145
PMCPMC9776005
OpenAlexW4312195057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.