Evidence map›Paper›PMID 36551127›Full record

ArticleBiosensors2022

A Compact Control System to Enable Automated Operation of Microfluidic Bioanalytical Assays.

Alan M Gonzalez-Suarez, Alexander Long, XuHai Huang, Alexander Revzin

Abstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. A passive flow microreactor for urine creatinine test.Microsystems & nanoengineering · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alan M Gonzalez-SuarezDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6442-4353
Alexander LongDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-3490-5049
XuHai HuangDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Alexander RevzinDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2M
A microfluidic device for blood analysis in neonatesR41HD100251 · NICHD · SERSENSE, INC. · PI STYBAYEVA, GULNAZ · 2019 to 2019
$223k
NICHD NIH HHS R41 HD100251NIDDK NIH HHS P30 DK084567NIH HHS DK084567NIH HHS HD100251
6 · The paper itself

Abstract

We describe a control system for operating valve-enabled microfluidic devices and leverage this control system to carry out a complex workflow of plasma separation from 8 μL of whole blood followed by on-chip mixing of plasma with assay reagents for biomarker detection. The control system incorporates pumps, digital pressure sensors, a microcontroller, solenoid valves and off-the-shelf components to deliver high and low air pressure in the desired temporal sequence to meter fluid flow and actuate microvalves. Importantly, our control system is portable, which is suitable for operating the microvalve-enabled microfluidic devices in the point-of-care setting.

Indexed as

Microfluidic Analytical TechniquesMicrofluidicsBiomarkersLab-On-A-Chip DevicesBiomarkersautomationmicrofluidicsmicromechanical valves

Identifiers

PMID36551127
PMCPMC9775492

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.