Evidence map›Paper›PMID 36551093›Full record

ReviewBiosensors2022

Recent Advances of NIR-II Emissive Semiconducting Polymer Dots for In Vivo Tumor Fluorescence Imaging and Theranostics.

Qidong Wei, Dingshi Xu, Tianyu Li, Xuehan He, Jiasi Wang, Yi Zhao, Lei Chen

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Binocular vision fusion enhanced 3D NIR-IIFundamental research · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qidong WeiSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Dingshi XuSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Tianyu LiSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Xuehan HeSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Shenzhen 518107, China.
Jiasi WangSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Yi ZhaoSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.
Lei ChenSchool of Biomedical Engineering, Sun Yat-Sen University, Shenzhen 518107, China.ORCID 0000-0001-6935-8340

Funding

Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province 2020B1212060077National Key Research and Development Program of China 2021YFF0703300National Natural Science Foundation of China No. 82204287
6 · The paper itself

Abstract

Accurate diagnosis and treatment of tumors, one of the top global health problems, has always been the research focus of scientists and doctors. Near-infrared (NIR) emissive semiconducting polymers dots (Pdots) have demonstrated bright prospects in field of in vivo tumor fluorescence imaging owing to some of their intrinsic advantages, including good water-dispersibility, facile surface-functionalization, easily tunable optical properties, and good biocompatibility. During recent years, much effort has been devoted to developing Pdots with emission bands located in the second near-infrared (NIR-II, 1000-1700 nm) region, which hold great advantages of higher spatial resolution, better signal-to-background ratios (SBR), and deeper tissue penetration for solid-tumor imaging in comparison with the visible region (400-680 nm) and the first near-infrared (NIR-I, 680-900 nm) window, by virtue of the reduced tissue autofluorescence, minimal photon scattering, and low photon absorption. In this review, we mainly summarize the latest advances of NIR-II emissive semiconducting Pdots for in vivo tumor fluorescence imaging, including molecular engineering to improve the fluorescence quantum yields and surface functionalization to elevate the tumor-targeting capability. We also present several NIR-II theranostic Pdots used for integrated tumor fluorescence diagnosis and photothermal/photodynamic therapy. Finally, we give our perspectives on future developments in this field.

Indexed as

NeoplasmsSemiconductorsHumansOptical ImagingPolymersPrecision MedicinePolymersfluorescence probesNIR-IIsemiconducting polymer dotstumor imagingtumor theranostics

Identifiers

PMID36551093
PMCPMC9775418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.