Evidence map›Paper›PMID 36551035›Full record

ReviewBiosensors2022

LAMP-Based Point-of-Care Biosensors for Rapid Pathogen Detection.

Dhrubajyoti Das, Cheng-Wen Lin, Han-Sheng Chuang

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Nucleic Acid Amplification Tests forPathogens (Basel, Switzerland) · 2026
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  19. Contribution ofCurrent issues in molecular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dhrubajyoti DasDepartment of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-4803-742X
Cheng-Wen LinDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.ORCID 0000-0003-0165-2652
Han-Sheng ChuangDepartment of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-7257-6565

Funding

National Science and Technology Council, Taiwan (R.O.C) 111-2221-E-006-066National Science and Technology Council, Taiwan (R.O.C) 111-2811-E-006-016
6 · The paper itself

Abstract

Seeking optimized infectious pathogen detection tools is of primary importance to lessen the spread of infections, allowing prompt medical attention for the infected. Among nucleic-acid-based sensing techniques, loop-mediated isothermal amplification is a promising method, as it provides rapid, sensitive, and specific detection of microbial and viral pathogens and has enormous potential to transform current point-of-care molecular diagnostics. In this review, the advances in LAMP-based point-of-care diagnostics assays developed during the past few years for rapid and sensitive detection of infectious pathogens are outlined. The numerous detection methods of LAMP-based biosensors are discussed in an end-point and real-time manner with ideal examples. We also summarize the trends in LAMP-on-a-chip modalities, such as classical microfluidic, paper-based, and digital LAMP, with their merits and limitations. Finally, we provide our opinion on the future improvement of on-chip LAMP methods. This review serves as an overview of recent breakthroughs in the LAMP approach and their potential for use in the diagnosis of existing and emerging diseases.

Indexed as

Biosensing TechniquesCommunicable DiseasesHumansMicrofluidicsMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesPoint-of-Care SystemsPoint-of-Care Testingbiosensorsdigital LAMPLAMP-on-a-chiploop-mediated isothermal amplificationmicrofluidicpathogen detectionpoint-of-care

Identifiers

PMID36551035
PMCPMC9775414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.