ArticleBioengineering (Basel, Switzerland)2022
Water-Absorbing Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Sponge for Hemostatic Agents.
Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Recent advances in medical hemostatic materials: Mechanisms, evaluation, and clinical perspectives.iScience · 2026Review
- Chemochromic Damage-Detecting and Recovery System Using Affordable Hydrogel.ACS applied materials & interfaces · 2025Article
- Development and Characterization of Self-Adhesive Polymeric Films with Antiallergic Effect.Polymers · 2025Article
- Article
- Wound Healing Enhancement and Physical Characterization of Bioadhesive Poly(acrylic acid)/Polyvinylpyrrolidone Complex Gels.Gels (Basel, Switzerland) · 2025Article
- 3D Printing of Naturally Derived Adhesive Hemostatic Sponge.Research (Washington, D.C.) · 2024Article
- Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis.Bioactive materials · 2023Review
- Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid.Polymers · 2023Review
- Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers.Biomedicines · 2023Review
- Topological Optimisation Structure Design for Personalisation of Hydrogel Controlled Drug Delivery System.Materials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoly(acrylic acid) (PAA) is a water-soluble synthetic polymer with tissue-adhesive properties. When PAA is mixed with polyvinylpyrrolidone (PVP) in water, it forms a water-insoluble precipitate that neither swells nor adheres to tissues. METHODS AND
resultsWe developed a novel solid/solution interface complexation method to obtain a water-swellable PAA/PVP complex. First, PAA solution was dried up in a vessel to form a film. The PAA film was then immersed in an aqueous PVP solution to obtain a highly swollen PAA/PVP hydrogel. Heat drying of the hydrogel yielded a transparent film, while freeze-drying the hydrogel provided a soft sponge. Both the PAA/PVP film and sponge could be re-swelled by water to obtain a bioadhesive gel. A relatively larger specific surface area of the sponge than that of the film led to a more rapid swelling and water absorption behavior and quick adhesion to tissues. The addition of hyaluronic acid (HA) improved the mechanical characteristics of the sponges. PAA/PVP/HA sponges had low cytotoxicity, and they exhibited high hemostatic efficiency in clinical studies after dialysis treatment or tooth extraction, even in patients on antithrombotic drugs.
conclusionsSuch bioadhesive materials consisting of low-toxicity polymers have a high potential for use in medical hemostatic devices.
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