ArticleJournal of clinical laboratory analysis2023
The association between serum anion gap and all-cause mortality of unselected adult patients: A retrospective cohort study of >20,000 patients.
Article in Journal of clinical laboratory analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Dynamics of serum anion gaps with in-hospital mortality: Analysis of the multi-open databases.PloS one · 2024Pooled it
- Association between anion gap trajectories and mortality in patients with acute cholangitis: a cohort study.Scientific reports · 2026Article
- Increased serum albumin corrected anion gap levels are associated with poor prognosis in sepsis-induced coagulopathy patients.PloS one · 2026Article
- Predicting ICU mortality in patients with abdominal aortic aneurysm: a nomogram based on MIMIC-IV and eICU-CRD.International journal of medical sciences · 2026Article
- How Long Do We Have? A Retrospective Review of Palliative Extubation in the Burn Unit.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Anion gap associated with 28-days all-cause mortality in Acute cholangitis patients admitted to the intensive care unit in MIMIC-IV database: a retrospective cohort study.Frontiers in medicine · 2025Article
- Increased serum albumin corrected anion gap levels are associated with poor prognosis in septic patients with liver cirrhosis.Scientific reports · 2024Article
- Association between Albumin-Corrected Anion Gap and Mortality in Patients with Cardiogenic Shock.Reviews in cardiovascular medicine · 2024Article
- The correlation between albumin-corrected anion gap and prognosis in patients with acute myocardial infarction.ESC heart failure · 2024Article
- The relationship between preoperative anemia and length of hospital stay among patients undergoing radical surgery for esophageal carcinoma: a single-centre retrospective study.BMC anesthesiology · 2023Article
- The association between serum anion gap and all-cause mortality of unselected adult patients: A retrospective cohort study of >20,000 patients.Journal of clinical laboratory analysis · 2023Article
- Albumin Corrected Anion Gap and the Risk of in-Hospital Mortality in Patients with Acute Pancreatitis: A Retrospective Cohort Study.Journal of inflammation research · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEven though the serum anion gap (AG) is frequently measured in clinical practice, there is not much research that has examined long-term mortality in unselected adult patients. Our study's objective was to investigate how serum anion gap levels could be used to predict death in unselected participants.
methodsThe relationship between baseline serum AG levels and short-, intermediate-, and long-term all-cause mortality in unselected adult patients is examined using the Cox proportional risk analysis, smoothed curve fitting, subgroup analysis, and Kaplan-Meier survival curves.
resultsAfter screening the database using the appropriate method, a total of 26,270 patients were enrolled in our study for the final data analysis. Our study used smoothed curve fit plots and COX proportional risk regression models incorporating cubic spline functions to evaluate the association between AG levels and all-cause mortality in a non-selected population, and the results indicated a non-linear relationship. In the fully adjusted model, we found that AG levels were positively associated with 30-day, 90-day, 365-day, and 4-year all-cause mortality in unselected adult patients with HRs of 1.08 95% CIs (1.06, 1.09); 1.08 95% CIs (1.06, 1.09); 1.08 95% CIs (1.07, 1.08); 1.07 95% CIs (1.06, 1.07).
conclusionSerum anion gap levels were positively correlated with all-cause mortality in unselected adult patients, with increasing levels of serum anion gap increasing patient mortality.
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