Evidence map›Paper›PMID 36550578›Full record

ArticleVirology journal2022

Adaptive immune responses and cytokine immune profiles in humans following prime and boost vaccination with the SARS-CoV-2 CoronaVac vaccine.

Chan Wang, Songhao Yang, Liangwei Duan, Xiancai Du, Jia Tao, Yana Wang, Jihui Yang, Yongxue Lv, Junliang Li, Cuiying Zhang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Chan Wang *School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Songhao Yang *School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Liangwei DuanHenan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Xiancai DuSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Jia TaoSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Yana WangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Jihui YangKey Laboratory of Hydatid Disease of Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Yongxue LvSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Junliang LiSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Cuiying ZhangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Jia WenSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Yazhou ZhuSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Liangliang ChangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.
Hui WangHenan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Qi WangSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China. wqmam@126.com.
Wei ZhaoSchool of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China. Weizhao@nxmu.edu.cn.
Ningxia Medical University · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdaptive immune response has been thought to play a key role in SARS-CoV-2 infection. The role of B cells, CD4 MATERIALS AND

methodsWe separate PBMC and plasma from blood samples. The differentiation and function of RBD-spcific CD4

resultsVaccine-induced CD4

conclusionTaken together, these results highlight the potential role of B cell and T cell responses in vaccine-induced long-term immunity.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralCOVID-19 VaccinesCytokinesEnzyme-Linked Immunospot AssayHumansImmunityLeukocytes, MononuclearVaccinationVaccines, InactivatedAntibodies, ViralCOVID-19 VaccinesCytokinessinovac COVID-19 vaccineVaccines, InactivatedCD4+T cellsCD8+T cellsInactivated vaccineMemory B cellsSARS-CoV-2

Identifiers

PMID36550578
PMCPMC9774075
OpenAlexW4312190944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.