Evidence map›Paper›PMID 36550568›Full record

ArticleCardiovascular diabetology2022

Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies.

Paul Valensi, Nicolas Barber-Chamoux, Amel Rezki, Céline Lambert, Bruno Pereira, Christian Dualé, Dominique Delmas, Martine Duclos

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02293135 naunknown statusnot on this map

Evaluation of the Action of the Stendo Pulsating Suit on Peripheral Microcirculation and on Endothelial Function in Diabetic Patients Without Complication

TypeinterventionalSponsorStendoRan2014 to 2015Enrolled16ConditionsType 2 DiabetesArmsVerum Stendo session on V1 and Phantom Stendo session on V2, Phantom Stendo session on V1 and Verum Stendo session on V2
NCT02359461 nacompletednot on this map

Evaluation of the Effect of Pulsatile Cuts Stendo3 on Vascular Function Patients With Diabetes Type 2

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2014 to 2018Enrolled46ConditionsType 2 DiabetesArmsCombination pulsatile Stendo3
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Paul ValensiEndocrinology, Diabetology and Nutrition Unit, AP-HP, Jean Verdier Hospital, Sorbonne Paris Nord University, CRNH-IdF, CINFO, Bondy, France. paul.valensi@aphp.fr.
Nicolas Barber-ChamouxDepartment of Cardiology, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Amel RezkiEndocrinology, Diabetology and Nutrition Unit, AP-HP, Jean Verdier Hospital, Sorbonne Paris Nord University, CRNH-IdF, CINFO, Bondy, France.
Céline LambertBiostatistics Unit, DRCI, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Bruno PereiraBiostatistics Unit, DRCI, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Christian DualéClinical Investigation Center (INSERM CIC1405), CHU Clermont-Ferrand, Clermont-Ferrand, France.
Dominique DelmasSESAME SAS, Charenton-Le-Pont, France.
Martine DuclosDepartment of Sports Medicine and Functional Explorations, CHU Clermont-Ferrand, INRAE, UNH, CRNH Auvergne, Clermont Auvergne University, Clermont-Ferrand, France.
Centre Hospitalier Universitaire de Clermont-Ferrand · FRAssistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRUnité de Nutrition Humaine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelium function is often impaired in patients with type 2 diabetes. We hypothesized that by improving endothelial function using diastole-synchronized compressions/decompressions (DSCD) to the lower body may improve the metabolic profile. The objective of this research was to evaluate the effects of single and multiple DSCD sessions on microcirculation, endothelium function and metabolic parameters of patients with type 2 diabetes.

methodsTwo monocentric, controlled, randomized cross-over studies (Study 1 and Study 2) were performed. In Study 1, 16 patients received one 20 min DSCD and one simulated (control) session at 2 week intervals; continuous glucose monitoring and cutaneous blood flow were recorded continuously before, during and after DSCD or Control session; other vascular assessments were performed before and after DSCD and control sessions. In Study 2, 38 patients received 60 min DSCD sessions three times/week for three months followed by a 4-6 week washout and 3 month control period (without simulated sessions); vascular, metabolic, body composition, physical activity and quality of life assessments were performed before and after 3 months.

resultsBoth studies showed significant, multiplex effects of DSCD sessions. In Study 1, cutaneous blood flow and endothelium function increased, and plasma and interstitial glucose levels after a standard breakfast decreased after DSCD sessions. In Study 2, cutaneous endothelium function improved, LDL-cholesterol and non-HDL cholesterol decreased, extra-cell water decreased and SF-36 Vitality score increased after 3 months of DSCD sessions.

conclusionsOur findings support the beneficial effect of DSCD on the endothelium and show concomitant beneficial metabolic and vitality effects. Future clinical trials need to test whether DSCD use translates into a preventive measure against microvascular diabetic complications and its progression. Trial registration ClinicalTrials.gov identifiers: NCT02293135 and NCT02359461.

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseBlood Glucose Self-MonitoringCross-Over StudiesDiastoleEndothelium, VascularGravity SuitsHumansQuality of LifeBlood GlucoseEndothelial functionMetabolic effectsPulsating compressionsShear stressType 2 diabetes

Identifiers

PMID36550568
PMCPMC9784294
OpenAlexW4312190255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.