Evidence map›Paper›PMID 36550386›Full record

ArticleIntensive care medicine experimental2022

Cerebrovascular pressure reactivity and brain tissue oxygen monitoring provide complementary information regarding the lower and upper limits of cerebral blood flow control in traumatic brain injury: a CAnadian High Resolution-TBI (CAHR-TBI) cohort study.

Alwyn Gomez, Mypinder Sekhon, Donald Griesdale, Logan Froese, Eleen Yang, Eric P Thelin, Rahul Raj, Marcel Aries, Clare Gallagher, Francis Bernard and 2 more

Abstract read
In one paragraph

Article in Intensive care medicine experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Association between blood pressure augmentation and brain tissue oxygenation in severe pediatric traumatic brain injury: preliminary findings.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  3. Article
  4. Article
  5. Observational
  6. Review
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  8. Review
  9. Review
  10. Article
  11. Article
  12. The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alwyn GomezDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. gomeza35@myumanitoba.ca.ORCID http://orcid.org/0000-0002-3737-2065
Mypinder SekhonDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Donald GriesdaleDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Logan FroeseBiomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada.
Eleen YangDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Eric P ThelinDepartment of Neurology, Karolinska University Hospital, Stockholm, Sweden.
Rahul RajDepartment of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Marcel AriesDepartment of Intensive Care, Maastricht University Medical Center, Maastricht, The Netherlands.
Clare GallagherSection of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Francis BernardSection of Critical Care, Department of Medicine, University of Montreal, Montreal, QC, Canada.
Andreas H Kramer *Department of Critical Care Medicine, University of Calgary, Calgary, Canada.
Frederick A Zeiler *Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Funding

Canada Foundation for Innovation Project #: 38583Institute of Neurosciences, Mental Health and Addiction Grant #: 472286Natural Sciences and Engineering Research Council of Canada ALLRP-576386-22Natural Sciences and Engineering Research Council of Canada DGECR-2022-00260Natural Sciences and Engineering Research Council of Canada RGPIN-2022-03621Research Manitoba Grant #: 3906The Erling-Persson Family Foundation and Region Stockholm Clinical Research Appointment FoUI-955376
6 · The paper itself

Abstract

backgroundBrain tissue oxygen tension (PbtO

methodsA retrospective multi-institution cohort study utilizing prospectively collected high-resolution physiologic data from the CAnadian High Resolution-TBI (CAHR-TBI) Research Collaborative database collected between 2011 and 2021 was performed. Included in the study were critically ill TBI patients with intracranial pressure (ICP), arterial blood pressure (ABP), and PbtO

resultsA total of 77 patients met the study inclusion criteria with a total of 377,744 min of physiologic data available for the analysis. PbtO

conclusionsIn this exploratory analysis of a multi-institution high-resolution physiology TBI database, PbtO

Indexed as

Brain tissue oxygen tensionCerebrovascular physiologyCerebrovascular reactivityMulti-modal monitoringTraumatic brain injury

Identifiers

PMID36550386
PMCPMC9780411

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.