Evidence map›Paper›PMID 36550362›Full record

ArticleScientific reports2022

Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.

Sarah Lapidus, Feimei Liu, Arnau Casanovas-Massana, Yile Dai, John D Huck, Carolina Lucas, Jon Klein, Renata B Filler, Madison S Strine, Mouhamad Sy and 53 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Prepandemic cross-reactive humoral immunity to SARS-CoV-2 in Africa: Systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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  18. SARS-CoV-2 seroprevalence in pregnant women during the first three COVID-19 waves in The Gambia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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4 · The record

Corrections and comments

  • Update of
    2021
5 · Who and what money

Authors and funding

63 authors at 17 institutions in 8 countries.

Sarah LapidusDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Feimei LiuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Arnau Casanovas-MassanaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Yile DaiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
John D HuckDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Carolina LucasDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Jon KleinDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Renata B FillerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Madison S StrineDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Mouhamad SyDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Awa B DemeDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Aida S BadianeLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Baba DieyeLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Ibrahima Mbaye NdiayeLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Younous DiedhiouLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Amadou Moctar MbayeLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Cheikh Tidiane DiagneDiaTROPIX Rapid Diagnostic Tests Facility, Institut Pasteur de Dakar, Dakar, Senegal.
Inés Vigan-WomasPôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Alassane MbengueG4-Malaria Experimental Genetic Approaches and Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Bacary D SadioPôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal.
Moussa M DiagnePôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal.
Adam J MooreDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Khadidiatou MangouG4-Malaria Experimental Genetic Approaches and Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Fatoumata DialloG4-Malaria Experimental Genetic Approaches and Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Seynabou D SeneG4-Malaria Experimental Genetic Approaches and Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Mariama N PouyeG4-Malaria Experimental Genetic Approaches and Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Rokhaya FayePôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Babacar DioufPôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Nivison NeryInstituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.
Federico CostaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Mitermayer G ReisDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
M Catherine MuenkerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Daniel Z HodsonDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Yannick MbargaDouala Military Hospital, Douala, Cameroon.
Ben Z KatzDivision of Infectious Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, USA.
Jason R AndrewsDivision of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Melissa CampbellYale Center for Clinical Investigation, Yale School of Medicine, New Haven, CT, USA.
Ariktha SrivathsanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Kathy KamathSerimmune, Inc., Goleta, CA, USA.
Elisabeth Baum-JonesSerimmune, Inc., Goleta, CA, USA.
Ousmane FayePôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal.
Amadou Alpha SallPôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal.
Juan Carlos Quintero VélezDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Michael CappelloDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Michael WilsonDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Choukri Ben-MamounDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
Richard TedderDepartment of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Myra McClureDepartment of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Peter CherepanovDepartment of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Fabrice A SoméInstitut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso.
Roch K DabiréInstitut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso.
Carole Else Eboumbou MoukokoDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, 2701, BP, Cameroon.
Jean Bosco OuédraogoInstitut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso.
Yap BoumMédecins Sans Frontières, University of Yaoundé and Epicentre, Yaoundé, Cameroon.
John ShonSerimmune, Inc., Goleta, CA, USA.
Daouda NdiayeLaboratory of Parasitology and Mycology, Aristide le Dantec Hospital, Cheikh Anta Diop University, Dakar, Senegal.
Adam WisnewskiDepartment of Internal Medicine, Yale Occupational and Environmental Medicine Program, Yale School of Medicine, New Haven, CT, USA.
Sunil ParikhDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Akiko IwasakiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Craig B WilenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Albert I KoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Aaron M RingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Amy K BeiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA. amy.bei@yale.edu.
Yale University · USInstitut Pasteur de Dakar · SNCheikh Anta Diop University · SNHôpital Aristide Le Dantec · SNInstitut de Recherche en Sciences de la Santé · BFSerimmune (United States) · USImperial College London · GBUniversity of Douala · CMFundação Oswaldo Cruz · BRHoward Hughes Medical Institute · USInstituto de Saúde · BRLurie Children's Hospital · USMinistério da Saúde · BRNoguchi Memorial Institute for Medical Research · GHStanford University · USThe Francis Crick Institute · GBUniversité de Yaoundé I · CM

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Yale Cancer Biology Training GrantT32CA193200 · NCI · YALE UNIVERSITY · PI PETER M GLAZER, Qin Yan · 2016 to 2026
$3.6M
Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine CandidatesR01AI168238 · NIAID · YALE UNIVERSITY · PI Amy Kristine Bei · 2022 to 2026
$3.5M
Emerging benzimidazole resistance in human hookwormsR01AI132452 · NIAID · YALE UNIVERSITY · PI CAPPELLO, MICHAEL · 2017 to 2021
$2.1M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
Employing genetic and genomic surveillance to reveal mechanisms of malaria parasite persistenceK01TW010496 · FIC · YALE UNIVERSITY · PI BEI, AMY KRISTINE · 2016 to 2021
$754k
FIC NIH HHS D43 TW010540FIC NIH HHS K01 TW010496NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NCI NIH HHS T32 CA193200NIAID NIH HHS K08 AI128043NIAID NIH HHS R01 AI132452NIAID NIH HHS R01 AI148467NIAID NIH HHS R01 AI168238
6 · The paper itself

Abstract

Sero-surveillance can monitor and project disease burden and risk. However, SARS-CoV-2 antibody test results can produce false positive results, limiting their efficacy as a sero-surveillance tool. False positive SARS-CoV-2 antibody results are associated with malaria exposure, and understanding this association is essential to interpret sero-surveillance results from malaria-endemic countries. Here, pre-pandemic samples from eight malaria endemic and non-endemic countries and four continents were tested by ELISA to measure SARS-CoV-2 Spike S1 subunit reactivity. Individuals with acute malaria infection generated substantial SARS-CoV-2 reactivity. Cross-reactivity was not associated with reactivity to other human coronaviruses or other SARS-CoV-2 proteins, as measured by peptide and protein arrays. ELISAs with deglycosylated and desialated Spike S1 subunits revealed that cross-reactive antibodies target sialic acid on N-linked glycans of the Spike protein. The functional activity of cross-reactive antibodies measured by neutralization assays showed that cross-reactive antibodies did not neutralize SARS-CoV-2 in vitro. Since routine use of glycosylated or sialated assays could result in false positive SARS-CoV-2 antibody results in malaria endemic regions, which could overestimate exposure and population-level immunity, we explored methods to increase specificity by reducing cross-reactivity. Overestimating population-level exposure to SARS-CoV-2 could lead to underestimates of risk of continued COVID-19 transmission in sub-Saharan Africa.

Indexed as

COVID-19MalariaAntibodies, ViralCross ReactionsEpitopesHumansN-Acetylneuraminic AcidSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, ViralEpitopesN-Acetylneuraminic AcidSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID36550362
PMCPMC9778468
OpenAlexW4312090540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.