ArticleNature biomedical engineering2023
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Catalyzing MRI: An Enzymatic Strategy forChemical & biomedical imaging · 2026Article
- Liposomal nanoprobes actuated by engineered water channels for sensitive detection of molecular targets by MRI.Nature biomedical engineering · 2026Article
- Responsive probes for in vivo magnetic resonance imaging of nitric oxide.Nature materials · 2025Article
- Organic functionality in responsive paramagnetic nanostructures.Frontiers in chemistry · 2025Review
- Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery.Communications materials · 2025Review
- Nanomaterial-enabled drug transport systems: a comprehensive exploration of current developments and future avenues in therapeutic delivery.3 Biotech · 2024Review
- Photoswitchable Endocytosis of Biomolecular Condensates in Giant Vesicles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents.Smart molecules : open access · 2024Article
- Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature.Nature biomedical engineering · 2024Article
- Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres.Journal of nanobiotechnology · 2024Article
- A Dual-Gene Reporter-Amplifier Architecture for Enhancing the Sensitivity of Molecular MRI by Water Exchange.Chembiochem : a European journal of chemical biology · 2024Article
- A dual-gene reporter-amplifier architecture for enhancing the sensitivity of molecular MRI by water exchange.bioRxiv : the preprint server for biology · 2024Article
- Nanomechanical action opens endo-lysosomal compartments.Nature communications · 2023Article
- Wireless agents for brain recording and stimulation modalities.Bioelectronic medicine · 2023Review
- Mapping light distribution in the brain via MRI.Nature biomedical engineering · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Characterizing sources and targets of illumination in living tissue is challenging. Here we show that spatial distributions of light in tissue can be mapped by using magnetic resonance imaging (MRI) in the presence of photosensitive nanoparticle probes. Each probe consists of a reservoir of paramagnetic molecules enclosed by a liposomal membrane incorporating photosensitive lipids. Incident light causes the photoisomerization of the lipids and alters hydrodynamic exchange across the membrane, thereby affecting longitudinal relaxation-weighted contrast in MRI. We injected the nanoparticles into the brains of live rats and used MRI to map responses to illumination profiles characteristic of widely used applications of photostimulation, photometry and phototherapy. The responses deviated from simple photon propagation models and revealed signatures of light scattering and nonlinear responsiveness. Paramagnetic liposomal nanoparticles may enable MRI to map a broad range of optical phenomena in deep tissue and other opaque environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.