ArticleNature neuroscience2023
The role of the lateral orbitofrontal cortex in creating cognitive maps.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- The effects of rTMS over orbitofrontal cortex on cognitive functions in first-episode schizophrenia.Psychological medicine · 2026Trial
- fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial.BMC medicine · 2026Trial
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices.PLoS biology · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex.Nature communications · 2025Article
- The reward positivity is insensitive to reinforcer devaluation.Cognitive, affective & behavioral neuroscience · 2025Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- The orbitofrontal cortex updates beliefs for state inference.bioRxiv : the preprint server for biology · 2025Article
- Striatal dopamine signals errors in prediction across different informational domains.Science advances · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We use mental models of the world-cognitive maps-to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead support behavior by underlying map creation. We tested between these two alternatives using outcome-specific devaluation and a high-potency chemogenetic approach. Selectively inactivating lOFC principal neurons when male rats learned distinct cue-outcome associations, but before outcome devaluation, disrupted subsequent inference, confirming a role for the lOFC in creating new maps. However, lOFC inactivation surprisingly led to generalized devaluation, a result that is inconsistent with a complete mapping failure. Using a reinforcement learning framework, we show that this effect is best explained by a circumscribed deficit in credit assignment precision during map construction, suggesting that the lOFC has a selective role in defining the specificity of associations that comprise cognitive maps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.