Evidence map›Paper›PMID 36549870›Full record

ArticleLife science alliance2023

Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies.

Annika Möller-Kerutt, Birgit Schönhoff, Yvonne Rellmann, Britta George, Daniela Anne Braun, Hermann Pavenstädt, Thomas Weide

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025
    Review
  3. CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes.American journal of physiology. Renal physiology · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Annika Möller-KeruttUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany.ORCID 0000-0003-2379-3800
Birgit SchönhoffUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany.
Yvonne RellmannInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Britta GeorgeUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany.
Daniela Anne BraunUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany.
Hermann PavenstädtUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany.
Thomas WeideUniversity Hospital of Muenster (UKM), Internal Medicine (MedD), Muenster, Germany weidet@uni-muenster.de a_moel20@uni-muenster.de.ORCID 0000-0002-2707-665X
University Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crumbs2 (CRB2) is a central component of the renal filtration barrier and part of the slit diaphragm, a unique cell contact formed by glomerular podocytes. Some

Indexed as

Membrane ProteinsNephrotic SyndromeCarrier ProteinsCell MembraneHumansMutation, MissenseCarrier ProteinsCRB2 protein, humanMembrane Proteins

Identifiers

PMID36549870
PMCPMC9780758
OpenAlexW4312091622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.